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Genetic scores to stratify risk of developing multiple islet autoantibodies and type 1 diabetes: A prospective study in children.
Bonifacio E, Beyerlein A, Hippich M, Winkler C, Vehik K, Weedon MN, Laimighofer M, Hattersley AT, Krumsiek J, Frohnert BI, Steck AK, Hagopian WA, Krischer JP, Lernmark Å, Rewers MJ, She JX, Toppari J, Akolkar B, Oram RA, Rich SS, Ziegler AG; TEDDY Study Group. Bonifacio E, et al. Among authors: hagopian wa. PLoS Med. 2018 Apr 3;15(4):e1002548. doi: 10.1371/journal.pmed.1002548. eCollection 2018 Apr. PLoS Med. 2018. PMID: 29614081 Free PMC article.
Clinical and research uses of genetic risk scores in type 1 diabetes.
Sharp SA, Weedon MN, Hagopian WA, Oram RA. Sharp SA, et al. Among authors: hagopian wa. Curr Opin Genet Dev. 2018 Jun;50:96-102. doi: 10.1016/j.gde.2018.03.009. Epub 2018 Apr 24. Curr Opin Genet Dev. 2018. PMID: 29702327 Free PMC article. Review.
A combined risk score enhances prediction of type 1 diabetes among susceptible children.
Ferrat LA, Vehik K, Sharp SA, Lernmark Å, Rewers MJ, She JX, Ziegler AG, Toppari J, Akolkar B, Krischer JP, Weedon MN, Oram RA, Hagopian WA; TEDDY Study Group. Ferrat LA, et al. Among authors: hagopian wa. Nat Med. 2020 Aug;26(8):1247-1255. doi: 10.1038/s41591-020-0930-4. Epub 2020 Aug 7. Nat Med. 2020. PMID: 32770166 Free PMC article.
Type 1 diabetes can present before the age of 6 months and is characterised by autoimmunity and rapid loss of beta cells.
Johnson MB, Patel KA, De Franco E, Hagopian W, Killian M, McDonald TJ, Tree TIM, Domingo-Vila C, Hudson M, Hammersley S, Dobbs R; EXE-T1D Consortium; Ellard S, Flanagan SE, Hattersley AT, Oram RA. Johnson MB, et al. Diabetologia. 2020 Dec;63(12):2605-2615. doi: 10.1007/s00125-020-05276-4. Epub 2020 Oct 8. Diabetologia. 2020. PMID: 33029656 Free PMC article.
Preventing type 1 diabetes in childhood.
Dayan CM, Besser REJ, Oram RA, Hagopian W, Vatish M, Bendor-Samuel O, Snape MD, Todd JA. Dayan CM, et al. Science. 2021 Jul 30;373(6554):506-510. doi: 10.1126/science.abi4742. Science. 2021. PMID: 34326231 Review.
218 results