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Structure-Activity Relationship Studies of α-Ketoamides as Inhibitors of the Phospholipase A and Acyltransferase Enzyme Family.
Zhou J, Mock ED, Al Ayed K, Di X, Kantae V, Burggraaff L, Stevens AF, Martella A, Mohr F, Jiang M, van der Wel T, Wendel TJ, Ofman TP, Tran Y, de Koster N, van Westen GJP, Hankemeier T, van der Stelt M. Zhou J, et al. Among authors: van der stelt m, van der wel t, van westen gjp. J Med Chem. 2020 Sep 10;63(17):9340-9359. doi: 10.1021/acs.jmedchem.0c00522. Epub 2020 Aug 13. J Med Chem. 2020. PMID: 32787138 Free PMC article.
Drug Discovery Maps, a Machine Learning Model That Visualizes and Predicts Kinome-Inhibitor Interaction Landscapes.
Janssen APA, Grimm SH, Wijdeven RHM, Lenselink EB, Neefjes J, van Boeckel CAA, van Westen GJP, van der Stelt M. Janssen APA, et al. Among authors: van der stelt m, van boeckel caa, van westen gjp. J Chem Inf Model. 2019 Mar 25;59(3):1221-1229. doi: 10.1021/acs.jcim.8b00640. Epub 2018 Nov 8. J Chem Inf Model. 2019. PMID: 30372617 Free PMC article.
Activity-Based Protein Profiling Identifies α-Ketoamides as Inhibitors for Phospholipase A2 Group XVI.
Zhou J, Mock ED, Martella A, Kantae V, Di X, Burggraaff L, Baggelaar MP, Al-Ayed K, Bakker A, Florea BI, Grimm SH, den Dulk H, Li CT, Mulder L, Overkleeft HS, Hankemeier T, van Westen GJP, van der Stelt M. Zhou J, et al. Among authors: van der stelt m, van westen gjp. ACS Chem Biol. 2019 Feb 15;14(2):164-169. doi: 10.1021/acschembio.8b00969. Epub 2019 Jan 18. ACS Chem Biol. 2019. PMID: 30620559 Free PMC article.
Comprehensive structure-activity-relationship of azaindoles as highly potent FLT3 inhibitors.
Grimm SH, Gagestein B, Keijzer JF, Liu N, Wijdeven RH, Lenselink EB, Tuin AW, van den Nieuwendijk AMCH, van Westen GJP, van Boeckel CAA, Overkleeft HS, Neefjes J, van der Stelt M. Grimm SH, et al. Among authors: van der stelt m, van boeckel caa, van westen gjp, van den nieuwendijk amch. Bioorg Med Chem. 2019 Mar 1;27(5):692-699. doi: 10.1016/j.bmc.2019.01.006. Epub 2019 Jan 14. Bioorg Med Chem. 2019. PMID: 30661740 Free article.
Advances and Challenges in Computational Target Prediction.
Sydow D, Burggraaff L, Szengel A, van Vlijmen HWT, IJzerman AP, van Westen GJP, Volkamer A. Sydow D, et al. Among authors: van westen gjp, van vlijmen hwt. J Chem Inf Model. 2019 May 28;59(5):1728-1742. doi: 10.1021/acs.jcim.8b00832. Epub 2019 Feb 28. J Chem Inf Model. 2019. PMID: 30817146 Review.
Development of Ubiquitin-Based Probe for Metalloprotease Deubiquitinases.
Hameed DS, Sapmaz A, Burggraaff L, Amore A, Slingerland CJ, van Westen GJP, Ovaa H. Hameed DS, et al. Among authors: van westen gjp. Angew Chem Int Ed Engl. 2019 Oct 7;58(41):14477-14482. doi: 10.1002/anie.201906790. Epub 2019 Aug 28. Angew Chem Int Ed Engl. 2019. PMID: 31381834
Novel natural and synthetic inhibitors of solute carriers SGLT1 and SGLT2.
Oranje P, Gouka R, Burggraaff L, Vermeer M, Chalet C, Duchateau G, van der Pijl P, Geldof M, de Roo N, Clauwaert F, Vanpaeschen T, Nicolaï J, de Bruyn T, Annaert P, IJzerman AP, van Westen GJP. Oranje P, et al. Among authors: van westen gjp, van der pijl p. Pharmacol Res Perspect. 2019 Jul 30;7(4):e00504. doi: 10.1002/prp2.504. eCollection 2019 Aug. Pharmacol Res Perspect. 2019. PMID: 31384471 Free PMC article.
Structure Kinetics Relationships and Molecular Dynamics Show Crucial Role for Heterocycle Leaving Group in Irreversible Diacylglycerol Lipase Inhibitors.
Janssen APA, van Hengst JMA, Béquignon OJM, Deng H, van Westen GJP, van der Stelt M. Janssen APA, et al. Among authors: van der stelt m, van westen gjp, van hengst jma. J Med Chem. 2019 Sep 12;62(17):7910-7922. doi: 10.1021/acs.jmedchem.9b00686. Epub 2019 Aug 30. J Med Chem. 2019. PMID: 31437392 Free PMC article.
120 results