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The Sphingosine Kinase 1 Inhibitor, PF543, Mitigates Pulmonary Fibrosis by Reducing Lung Epithelial Cell mtDNA Damage and Recruitment of Fibrogenic Monocytes.
Cheresh P, Kim SJ, Huang LS, Watanabe S, Joshi N, Williams KJN, Chi M, Lu Z, Harijith A, Yeldandi A, Lam AP, Gottardi C, Misharin AV, Budinger GRS, Natarajan V, Kamp DW. Cheresh P, et al. Among authors: yeldandi a. Int J Mol Sci. 2020 Aug 5;21(16):5595. doi: 10.3390/ijms21165595. Int J Mol Sci. 2020. PMID: 32764262 Free PMC article.
Mitochondrial catalase overexpressed transgenic mice are protected against lung fibrosis in part via preventing alveolar epithelial cell mitochondrial DNA damage.
Kim SJ, Cheresh P, Jablonski RP, Morales-Nebreda L, Cheng Y, Hogan E, Yeldandi A, Chi M, Piseaux R, Ridge K, Michael Hart C, Chandel N, Scott Budinger GR, Kamp DW. Kim SJ, et al. Among authors: yeldandi a. Free Radic Biol Med. 2016 Dec;101:482-490. doi: 10.1016/j.freeradbiomed.2016.11.007. Epub 2016 Nov 11. Free Radic Biol Med. 2016. PMID: 27840320 Free PMC article.
SIRT3 deficiency promotes lung fibrosis by augmenting alveolar epithelial cell mitochondrial DNA damage and apoptosis.
Jablonski RP, Kim SJ, Cheresh P, Williams DB, Morales-Nebreda L, Cheng Y, Yeldandi A, Bhorade S, Pardo A, Selman M, Ridge K, Gius D, Budinger GRS, Kamp DW. Jablonski RP, et al. Among authors: yeldandi a. FASEB J. 2017 Jun;31(6):2520-2532. doi: 10.1096/fj.201601077R. Epub 2017 Mar 3. FASEB J. 2017. PMID: 28258190 Free PMC article.
Asbestos- or bleomycin-induced lung fibrosis, AEC mtDNA damage, and apoptosis in wild-type mice were amplified in Sirt3(-/-) animals. These data suggest a novel role for SIRT3 deficiency in mediating AEC mtDNA damage, apoptosis, and lung fibrosis....-J., Cheresh, P., Willi …
Asbestos- or bleomycin-induced lung fibrosis, AEC mtDNA damage, and apoptosis in wild-type mice were amplified in Sirt3(-/-) animals. These …
Mitochondrial 8-oxoguanine DNA glycosylase mitigates alveolar epithelial cell PINK1 deficiency, mitochondrial DNA damage, apoptosis, and lung fibrosis.
Kim SJ, Cheresh P, Jablonski RP, Rachek L, Yeldandi A, Piseaux-Aillon R, Ciesielski MJ, Ridge K, Gottardi C, Lam AP, Pardo A, Selman M, Natarajan V, Kamp DW. Kim SJ, et al. Among authors: yeldandi a. Am J Physiol Lung Cell Mol Physiol. 2020 May 1;318(5):L1084-L1096. doi: 10.1152/ajplung.00069.2019. Epub 2020 Mar 25. Am J Physiol Lung Cell Mol Physiol. 2020. PMID: 32209025 Free PMC article.
146 results