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The histone methyltransferase DOT1L prevents antigen-independent differentiation and safeguards epigenetic identity of CD8+ T cells.
Kwesi-Maliepaard EM, Aslam MA, Alemdehy MF, van den Brand T, McLean C, Vlaming H, van Welsem T, Korthout T, Lancini C, Hendriks S, Ahrends T, van Dinther D, den Haan JMM, Borst J, de Wit E, van Leeuwen F, Jacobs H. Kwesi-Maliepaard EM, et al. Among authors: van welsem t. Proc Natl Acad Sci U S A. 2020 Aug 25;117(34):20706-20716. doi: 10.1073/pnas.1920372117. Epub 2020 Aug 6. Proc Natl Acad Sci U S A. 2020. PMID: 32764145 Free PMC article.
Recombination-induced tag exchange to track old and new proteins.
Verzijlbergen KF, Menendez-Benito V, van Welsem T, van Deventer SJ, Lindstrom DL, Ovaa H, Neefjes J, Gottschling DE, van Leeuwen F. Verzijlbergen KF, et al. Among authors: van deventer sj, van leeuwen f, van welsem t. Proc Natl Acad Sci U S A. 2010 Jan 5;107(1):64-8. doi: 10.1073/pnas.0911164107. Epub 2009 Dec 14. Proc Natl Acad Sci U S A. 2010. PMID: 20018668 Free PMC article.
Progressive methylation of ageing histones by Dot1 functions as a timer.
De Vos D, Frederiks F, Terweij M, van Welsem T, Verzijlbergen KF, Iachina E, de Graaf EL, Altelaar AF, Oudgenoeg G, Heck AJ, Krijgsveld J, Bakker BM, van Leeuwen F. De Vos D, et al. Among authors: van leeuwen f, van welsem t. EMBO Rep. 2011 Sep 1;12(9):956-62. doi: 10.1038/embor.2011.131. EMBO Rep. 2011. PMID: 21760613 Free PMC article.
A network model of the molecular organization of chromatin in Drosophila.
van Bemmel JG, Filion GJ, Rosado A, Talhout W, de Haas M, van Welsem T, van Leeuwen F, van Steensel B. van Bemmel JG, et al. Among authors: van leeuwen f, van welsem t, van steensel b. Mol Cell. 2013 Feb 21;49(4):759-71. doi: 10.1016/j.molcel.2013.01.040. Mol Cell. 2013. PMID: 23438860 Free article.
32 results