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Myeloperoxidase Modulates Inflammation in Generalized Pustular Psoriasis and Additional Rare Pustular Skin Diseases.
Haskamp S, Bruns H, Hahn M, Hoffmann M, Gregor A, Löhr S, Hahn J, Schauer C, Ringer M, Flamann C, Frey B, Lesner A, Thiel CT, Ekici AB, von Hörsten S, Aßmann G, Riepe C, Euler M, Schäkel K, Philipp S, Prinz JC, Mößner R, Kersting F, Sticherling M, Sefiani A, Lyahyai J, Sondermann W, Oji V, Schulz P, Wilsmann-Theis D, Sticht H, Schett G, Reis A, Uebe S, Frey S, Hüffmeier U. Haskamp S, et al. Among authors: lesner a. Am J Hum Genet. 2020 Sep 3;107(3):527-538. doi: 10.1016/j.ajhg.2020.07.001. Epub 2020 Aug 5. Am J Hum Genet. 2020. PMID: 32758447 Free PMC article.
Aggregated neutrophil extracellular traps resolve inflammation by proteolysis of cytokines and chemokines and protection from antiproteases.
Hahn J, Schauer C, Czegley C, Kling L, Petru L, Schmid B, Weidner D, Reinwald C, Biermann MHC, Blunder S, Ernst J, Lesner A, Bäuerle T, Palmisano R, Christiansen S, Herrmann M, Bozec A, Gruber R, Schett G, Hoffmann MH. Hahn J, et al. Among authors: lesner a. FASEB J. 2019 Jan;33(1):1401-1414. doi: 10.1096/fj.201800752R. Epub 2018 Aug 21. FASEB J. 2019. PMID: 30130433 Free PMC article.
In summary, neutrophil-driven proteolysis of inflammatory mediators works as a built-in safeguard for inflammation. The absence of this negative feedback mechanism might be responsible for the nonresolving periodontitis seen in PLS.-Hahn, J., Schauer, C., Czegley, C., Klin …
In summary, neutrophil-driven proteolysis of inflammatory mediators works as a built-in safeguard for inflammation. The absence of th …
Three wavelength substrate system of neutrophil serine proteinases.
Wysocka M, Lesner A, Gruba N, Korkmaz B, Gauthier F, Kitamatsu M, Łęgowska A, Rolka K. Wysocka M, et al. Among authors: lesner a. Anal Chem. 2012 Aug 21;84(16):7241-8. doi: 10.1021/ac301684w. Epub 2012 Aug 8. Anal Chem. 2012. PMID: 22823539
Digestive Inflammation: Role of Proteolytic Dysregulation.
Mariaule V, Kriaa A, Soussou S, Rhimi S, Boudaya H, Hernandez J, Maguin E, Lesner A, Rhimi M. Mariaule V, et al. Among authors: lesner a. Int J Mol Sci. 2021 Mar 10;22(6):2817. doi: 10.3390/ijms22062817. Int J Mol Sci. 2021. PMID: 33802197 Free PMC article. Review.
Neutrophilic Cathepsin C Is Maturated by a Multistep Proteolytic Process and Secreted by Activated Cells during Inflammatory Lung Diseases.
Hamon Y, Legowska M, Hervé V, Dallet-Choisy S, Marchand-Adam S, Vanderlynden L, Demonte M, Williams R, Scott CJ, Si-Tahar M, Heuzé-Vourc'h N, Lalmanach G, Jenne DE, Lesner A, Gauthier F, Korkmaz B. Hamon Y, et al. Among authors: lesner a. J Biol Chem. 2016 Apr 15;291(16):8486-99. doi: 10.1074/jbc.M115.707109. Epub 2016 Feb 16. J Biol Chem. 2016. PMID: 26884336 Free PMC article.
Distance between the basic group of the amino acid residue's side chain in position P1 of trypsin inhibitor CMTI-III and Asp189 in the substrate pocket of trypsin has an essential influence on the inhibitory activity.
Jaśkiewicz A, Lesner A, Rózycki J, Rodziewicz S, Rolka K, Ragnarsson U, Kupryszewski G. Jaśkiewicz A, et al. Among authors: lesner a. Biochem Biophys Res Commun. 1997 Nov 26;240(3):869-71. doi: 10.1006/bbrc.1997.7752. Biochem Biophys Res Commun. 1997. PMID: 9398660
127 results