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TBK1 phosphorylates mutant Huntingtin and suppresses its aggregation and toxicity in Huntington's disease models.
Hegde RN, Chiki A, Petricca L, Martufi P, Arbez N, Mouchiroud L, Auwerx J, Landles C, Bates GP, Singh-Bains MK, Dragunow M, Curtis MA, Faull RL, Ross CA, Caricasole A, Lashuel HA. Hegde RN, et al. Among authors: arbez n. EMBO J. 2020 Sep 1;39(17):e104671. doi: 10.15252/embj.2020104671. Epub 2020 Aug 5. EMBO J. 2020. PMID: 32757223 Free PMC article.
Nemo-like kinase reduces mutant huntingtin levels and mitigates Huntington's disease.
Jiang M, Zhang X, Liu H, LeBron J, Alexandris A, Peng Q, Gu H, Yang F, Li Y, Wang R, Hou Z, Arbez N, Ren Q, Dong JL, Whela E, Wang R, Ratovitski T, Troncoso JC, Mori S, Ross CA, Lim J, Duan W. Jiang M, et al. Among authors: arbez n. Hum Mol Genet. 2020 May 28;29(8):1340-1352. doi: 10.1093/hmg/ddaa061. Hum Mol Genet. 2020. PMID: 32242231 Free PMC article.
trans-(-)-ε-Viniferin increases mitochondrial sirtuin 3 (SIRT3), activates AMP-activated protein kinase (AMPK), and protects cells in models of Huntington Disease.
Fu J, Jin J, Cichewicz RH, Hageman SA, Ellis TK, Xiang L, Peng Q, Jiang M, Arbez N, Hotaling K, Ross CA, Duan W. Fu J, et al. Among authors: arbez n. J Biol Chem. 2012 Jul 13;287(29):24460-72. doi: 10.1074/jbc.M112.382226. Epub 2012 May 30. J Biol Chem. 2012. PMID: 22648412 Free PMC article.
36 results