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Topical 'dual-soft' glucocorticoid receptor agonist for dermatology.
Dack KN, Johnson PS, Henriksson K, Eirefelt S, Carnerup MA, Stahlhut M, Ollerstam AK. Dack KN, et al. Among authors: johnson ps. Bioorg Med Chem Lett. 2020 Sep 1;30(17):127402. doi: 10.1016/j.bmcl.2020.127402. Epub 2020 Jul 13. Bioorg Med Chem Lett. 2020. PMID: 32738970
Discovery of PF-184563, a potent and selective V1a antagonist for the treatment of dysmenorrhoea. The influence of compound flexibility on microsomal stability.
Johnson PS, Ryckmans T, Bryans J, Beal DM, Dack KN, Feeder N, Harrison A, Lewis M, Mason HJ, Mills J, Newman J, Pasquinet C, Rawson DJ, Roberts LR, Russell R, Spark D, Stobie A, Underwood TJ, Ward R, Wheeler S. Johnson PS, et al. Bioorg Med Chem Lett. 2011 Oct 1;21(19):5684-7. doi: 10.1016/j.bmcl.2011.08.038. Epub 2011 Aug 12. Bioorg Med Chem Lett. 2011. PMID: 21885275
Discovery of aryloxy tetramethylcyclobutanes as novel androgen receptor antagonists.
Guo C, Linton A, Kephart S, Ornelas M, Pairish M, Gonzalez J, Greasley S, Nagata A, Burke BJ, Edwards M, Hosea N, Kang P, Hu W, Engebretsen J, Briere D, Shi M, Gukasyan H, Richardson P, Dack K, Underwood T, Johnson P, Morell A, Felstead R, Kuruma H, Matsimoto H, Zoubeidi A, Gleave M, Los G, Fanjul AN. Guo C, et al. J Med Chem. 2011 Nov 10;54(21):7693-704. doi: 10.1021/jm201059s. Epub 2011 Oct 7. J Med Chem. 2011. PMID: 21936524
Design of potent and selective inhibitors to overcome clinical anaplastic lymphoma kinase mutations resistant to crizotinib.
Huang Q, Johnson TW, Bailey S, Brooun A, Bunker KD, Burke BJ, Collins MR, Cook AS, Cui JJ, Dack KN, Deal JG, Deng YL, Dinh D, Engstrom LD, He M, Hoffman J, Hoffman RL, Johnson PS, Kania RS, Lam H, Lam JL, Le PT, Li Q, Lingardo L, Liu W, Lu MW, McTigue M, Palmer CL, Richardson PF, Sach NW, Shen H, Smeal T, Smith GL, Stewart AE, Timofeevski S, Tsaparikos K, Wang H, Zhu H, Zhu J, Zou HY, Edwards MP. Huang Q, et al. Among authors: johnson tw, johnson ps. J Med Chem. 2014 Feb 27;57(4):1170-87. doi: 10.1021/jm401805h. Epub 2014 Feb 6. J Med Chem. 2014. PMID: 24432909 Free article.
Designing rapid onset selective serotonin re-uptake inhibitors. 2: structure-activity relationships of substituted (aryl)benzylamines.
Middleton DS, Andrews M, Glossop P, Gymer G, Hepworth D, Jessiman A, Johnson PS, Mackenny M, Pitcher MJ, Rooker T, Stobie A, Tang K, Morgan P. Middleton DS, et al. Among authors: johnson ps. Bioorg Med Chem Lett. 2008 Jul 15;18(14):4018-21. doi: 10.1016/j.bmcl.2008.06.001. Epub 2008 Jun 5. Bioorg Med Chem Lett. 2008. PMID: 18571404
Designing rapid onset selective serotonin re-uptake inhibitors. Part 3: Site-directed metabolism as a strategy to avoid active circulating metabolites: structure-activity relationships of (thioalkyl)phenoxy benzylamines.
Middleton DS, Andrews M, Glossop P, Gymer G, Hepworth D, Jessiman A, Johnson PS, MacKenny M, Stobie A, Tang K, Morgan P, Jones B. Middleton DS, et al. Among authors: johnson ps. Bioorg Med Chem Lett. 2008 Oct 1;18(19):5303-6. doi: 10.1016/j.bmcl.2008.08.040. Epub 2008 Aug 14. Bioorg Med Chem Lett. 2008. PMID: 18782666
Designing rapid onset selective serotonin re-uptake inhibitors. Part 1: Structure-activity relationships of substituted (1S,4S)-4-(3,4-dichlorophenyl)-N-methyl-1,2,3,4-tetrahydro-1-naphthaleneamine.
Middleton DS, Andrews M, Glossop P, Gymer G, Jessiman A, Johnson PS, Mackenny M, Pitcher MJ, Rooker T, Stobie A, Tang K, Morgan P. Middleton DS, et al. Among authors: johnson ps. Bioorg Med Chem Lett. 2006 Mar 1;16(5):1434-9. doi: 10.1016/j.bmcl.2005.11.031. Epub 2005 Nov 28. Bioorg Med Chem Lett. 2006. PMID: 16314097
94 results