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Modulating disease-relevant tau oligomeric strains by small molecules.
Lo Cascio F, Garcia S, Montalbano M, Puangmalai N, McAllen S, Pace A, Palumbo Piccionello A, Kayed R. Lo Cascio F, et al. Among authors: kayed r. J Biol Chem. 2020 Oct 30;295(44):14807-14825. doi: 10.1074/jbc.RA120.014630. Epub 2020 Jul 31. J Biol Chem. 2020. PMID: 32737202 Free PMC article.
Small misfolded Tau species are internalized via bulk endocytosis and anterogradely and retrogradely transported in neurons.
Wu JW, Herman M, Liu L, Simoes S, Acker CM, Figueroa H, Steinberg JI, Margittai M, Kayed R, Zurzolo C, Di Paolo G, Duff KE. Wu JW, et al. Among authors: kayed r. J Biol Chem. 2013 Jan 18;288(3):1856-70. doi: 10.1074/jbc.M112.394528. Epub 2012 Nov 27. J Biol Chem. 2013. PMID: 23188818 Free PMC article.
Recent data have shown that misfolded Tau can be internalized by cells in vitro (Frost, B., Jacks, R. L., and Diamond, M. I. (2009) J. Biol. Chem. 284, 12845-12852) and propagate pathology in vivo (Clavaguera, F., Bolmont, T., Crowther, R. ...J., Kiritoshi, T., Neug …
Recent data have shown that misfolded Tau can be internalized by cells in vitro (Frost, B., Jacks, R. L., and Diamond, M. I. (2009) J …
Tau aggregates as immunotherapeutic targets.
Castillo-Carranza DL, Lasagna-Reeves CA, Kayed R. Castillo-Carranza DL, et al. Among authors: kayed r. Front Biosci (Schol Ed). 2013 Jan 1;5(2):426-38. doi: 10.2741/s381. Front Biosci (Schol Ed). 2013. PMID: 23277060 Free article. Review.
Formation and propagation of tau oligomeric seeds.
Gerson JE, Kayed R. Gerson JE, et al. Among authors: kayed r. Front Neurol. 2013 Jul 17;4:93. doi: 10.3389/fneur.2013.00093. eCollection 2013. Front Neurol. 2013. PMID: 23882255 Free PMC article.
Passive immunization with Tau oligomer monoclonal antibody reverses tauopathy phenotypes without affecting hyperphosphorylated neurofibrillary tangles.
Castillo-Carranza DL, Sengupta U, Guerrero-Muñoz MJ, Lasagna-Reeves CA, Gerson JE, Singh G, Estes DM, Barrett AD, Dineley KT, Jackson GR, Kayed R. Castillo-Carranza DL, et al. Among authors: kayed r. J Neurosci. 2014 Mar 19;34(12):4260-72. doi: 10.1523/JNEUROSCI.3192-13.2014. J Neurosci. 2014. PMID: 24647946 Free PMC article.
189 results