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Discovery of Protein-Protein Interaction Inhibitors by Integrating Protein Engineering and Chemical Screening Platforms.
Maculins T, Garcia-Pardo J, Skenderovic A, Gebel J, Putyrski M, Vorobyov A, Busse P, Varga G, Kuzikov M, Zaliani A, Rahighi S, Schaeffer V, Parnham MJ, Sidhu SS, Ernst A, Dötsch V, Akutsu M, Dikic I. Maculins T, et al. Among authors: parnham mj. Cell Chem Biol. 2020 Nov 19;27(11):1441-1451.e7. doi: 10.1016/j.chembiol.2020.07.010. Epub 2020 Jul 28. Cell Chem Biol. 2020. PMID: 32726587 Free article.
IL-38 Ameliorates Skin Inflammation and Limits IL-17 Production from γδ T Cells.
Han Y, Mora J, Huard A, da Silva P, Wiechmann S, Putyrski M, Schuster C, Elwakeel E, Lang G, Scholz A, Scholz T, Schmid T, de Bruin N, Billuart P, Sala C, Burkhardt H, Parnham MJ, Ernst A, Brüne B, Weigert A. Han Y, et al. Among authors: parnham mj. Cell Rep. 2019 Apr 16;27(3):835-846.e5. doi: 10.1016/j.celrep.2019.03.082. Cell Rep. 2019. PMID: 30995480 Free article.
Tolerizing CTL by Sustained Hepatic PD-L1 Expression Provides a New Therapy Approach in Mouse Sepsis.
von Knethen A, Schäfer A, Kuchler L, Knape T, Christen U, Hintermann E, Fißlthaler B, Schröder K, Brandes RP, Genz B, Abshagen K, Pützer BM, Sha LK, Weigert A, Syed SN, Schulz M, Shah AM, Ernst A, Putyrski M, Finkelmeier F, Pesic M, Greten F, Hogardt M, Kempf VAJ, Gunne S, Parnham MJ, Brüne B. von Knethen A, et al. Among authors: parnham mj. Theranostics. 2019 Mar 16;9(7):2003-2016. doi: 10.7150/thno.28057. eCollection 2019. Theranostics. 2019. PMID: 31037153 Free PMC article.
Targeting CYP2J to reduce paclitaxel-induced peripheral neuropathic pain.
Sisignano M, Angioni C, Park CK, Meyer Dos Santos S, Jordan H, Kuzikov M, Liu D, Zinn S, Hohman SW, Schreiber Y, Zimmer B, Schmidt M, Lu R, Suo J, Zhang DD, Schäfer SM, Hofmann M, Yekkirala AS, de Bruin N, Parnham MJ, Woolf CJ, Ji RR, Scholich K, Geisslinger G. Sisignano M, et al. Among authors: parnham mj. Proc Natl Acad Sci U S A. 2016 Nov 1;113(44):12544-12549. doi: 10.1073/pnas.1613246113. Epub 2016 Oct 17. Proc Natl Acad Sci U S A. 2016. PMID: 27791151 Free PMC article.
Structure optimization of a new class of PPARγ antagonists.
Hernandez-Olmos V, Knape T, Heering J, von Knethen A, Kilu W, Kaiser A, Wurglics M, Helmstädter M, Merk D, Schubert-Zsilavecz M, Parnham MJ, Steinhilber D, Proschak E. Hernandez-Olmos V, et al. Among authors: parnham mj. Bioorg Med Chem. 2019 Nov 1;27(21):115082. doi: 10.1016/j.bmc.2019.115082. Epub 2019 Aug 27. Bioorg Med Chem. 2019. PMID: 31548084
Toxicity screening of liposomes.
Parnham MJ, Wetzig H. Parnham MJ, et al. Chem Phys Lipids. 1993 Sep;64(1-3):263-74. doi: 10.1016/0009-3084(93)90070-j. Chem Phys Lipids. 1993. PMID: 8242838 Review.
Drug Repurposing for the Development of Novel Analgesics.
Sisignano M, Parnham MJ, Geisslinger G. Sisignano M, et al. Among authors: parnham mj. Trends Pharmacol Sci. 2016 Mar;37(3):172-183. doi: 10.1016/j.tips.2015.11.006. Epub 2015 Dec 17. Trends Pharmacol Sci. 2016. PMID: 26706620
Long-term stimulation of toll-like receptor-2 and -4 upregulates 5-LO and 15-LO-2 expression thereby inducing a lipid mediator shift in human monocyte-derived macrophages.
Ebert R, Cumbana R, Lehmann C, Kutzner L, Toewe A, Ferreirós N, Parnham MJ, Schebb NH, Steinhilber D, Kahnt AS. Ebert R, et al. Among authors: parnham mj. Biochim Biophys Acta Mol Cell Biol Lipids. 2020 Sep;1865(9):158702. doi: 10.1016/j.bbalip.2020.158702. Epub 2020 Mar 25. Biochim Biophys Acta Mol Cell Biol Lipids. 2020. PMID: 32222425 Free article.
213 results