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Page 1
Optimization of a series of potent, selective and orally bioavailable SYK inhibitors.
Grimster NP, Gingipalli L, Barlaam B, Su Q, Zheng X, Watson D, Wang H, Simpson I, Pike A, Balazs A, Boiko S, Ikeda TP, Impastato AC, Jones NH, Kawatkar S, Kemmitt P, Lamont S, Patel J, Read J, Sarkar U, Sha L, Tomlinson RC, Wang H, Wilson DM, Zehnder TE, Wang L, Wang P, Goldberg FW, Shao W, Fawell S, Dry H, Dowling JE, Edmondson SD. Grimster NP, et al. Among authors: zehnder te. Bioorg Med Chem Lett. 2020 Oct 1;30(19):127433. doi: 10.1016/j.bmcl.2020.127433. Epub 2020 Jul 24. Bioorg Med Chem Lett. 2020. PMID: 32717371
Tetrahydropyridines via FeCl3-Catalyzed Carbonyl-Olefin Metathesis.
Rykaczewski KA, Groso EJ, Vonesh HL, Gaviria MA, Richardson AD, Zehnder TE, Schindler CS. Rykaczewski KA, et al. Among authors: zehnder te. Org Lett. 2020 Apr 3;22(7):2844-2848. doi: 10.1021/acs.orglett.0c00918. Epub 2020 Mar 23. Org Lett. 2020. PMID: 32202807
Hydrazone and Oxime Olefination via Ruthenium Alkylidenes.
Nasrallah DJ, Zehnder TE, Ludwig JR, Steigerwald DC, Kiernicki JJ, Szymczak NK, Schindler CS. Nasrallah DJ, et al. Among authors: zehnder te. Angew Chem Int Ed Engl. 2022 May 23;61(22):e202112101. doi: 10.1002/anie.202112101. Epub 2022 Mar 29. Angew Chem Int Ed Engl. 2022. PMID: 35275430 Free PMC article.
Optimization of a series of novel, potent and selective Macrocyclic SYK inhibitors.
Grimster NP, Gingipalli L, Balazs A, Barlaam B, Boiko S, Boyd S, Dry H, Goldberg FW, Ikeda T, Johnson T, Kawatkar S, Kemmitt P, Lamont S, Lorthioir O, Mfuh A, Patel J, Pike A, Read J, Romero R, Sarkar U, Sha L, Simpson I, Song K, Su Q, Wang H, Watson D, Wu A, Zehnder TE, Zheng X, Li S, Dong Z, Yang D, Song Y, Wang P, Liu X, Dowling JE, Edmondson SD. Grimster NP, et al. Among authors: zehnder te. Bioorg Med Chem Lett. 2023 Jul 15;91:129352. doi: 10.1016/j.bmcl.2023.129352. Epub 2023 Jun 2. Bioorg Med Chem Lett. 2023. PMID: 37270074