Li XK - Search Results

1

Development of disulfide-derived fructose-1,6-bisphosphatase (FBPase) covalent inhibitors for the treatment of type 2 diabetes.

Xu YX, Huang YY, Song RR, Ren YL, Chen X, Zhang C, Mao F, Li XK, Zhu J, Ni SS, Wan J, Li J. Xu YX, et al. Among authors: li xk, li j. Eur J Med Chem. 2020 Oct 1;203:112500. doi: 10.1016/j.ejmech.2020.112500. Epub 2020 Jul 15. Eur J Med Chem. 2020. PMID: 32711108

2

A Metal-free Approach to 3-Aryl-3-hydroxy-2-oxindoles by Treatment of 3-Acyloxy-2-oxindoles with Diaryliodonium Salts.

Li X, Ni W, Mao F, Wang W, Li J. Li X, et al. Chem Asian J. 2016 Jan;11(2):226-30. doi: 10.1002/asia.201500854. Epub 2015 Nov 3. Chem Asian J. 2016. PMID: 26481872

3

Development of Multifunctional Pyrimidinylthiourea Derivatives as Potential Anti-Alzheimer Agents.

Li X, Wang H, Lu Z, Zheng X, Ni W, Zhu J, Fu Y, Lian F, Zhang N, Li J, Zhang H, Mao F. Li X, et al. J Med Chem. 2016 Sep 22;59(18):8326-44. doi: 10.1021/acs.jmedchem.6b00636. Epub 2016 Sep 6. J Med Chem. 2016. PMID: 27552582

4

Discovery of Potent, Selective Stem Cell Factor Receptor/Platelet Derived Growth Factor Receptor Alpha (c-KIT/PDGFRα) Dual Inhibitor for the Treatment of Imatinib-Resistant Gastrointestinal Stromal Tumors (GISTs).

Lu Y, Mao F, Li X, Zheng X, Wang M, Xu Q, Zhu J, Li J. Lu Y, et al. J Med Chem. 2017 Jun 22;60(12):5099-5119. doi: 10.1021/acs.jmedchem.7b00468. Epub 2017 Jun 7. J Med Chem. 2017. PMID: 28541695

5

Novel Vilazodone-Tacrine Hybrids as Potential Multitarget-Directed Ligands for the Treatment of Alzheimer's Disease Accompanied with Depression: Design, Synthesis, and Biological Evaluation.

Li X, Wang H, Xu Y, Liu W, Gong Q, Wang W, Qiu X, Zhu J, Mao F, Zhang H, Li J. Li X, et al. ACS Chem Neurosci. 2017 Dec 20;8(12):2708-2721. doi: 10.1021/acschemneuro.7b00259. Epub 2017 Sep 19. ACS Chem Neurosci. 2017. PMID: 28872831

6

Novel Inhibitors of Staphyloxanthin Virulence Factor in Comparison with Linezolid and Vancomycin versus Methicillin-Resistant, Linezolid-Resistant, and Vancomycin-Intermediate Staphylococcus aureus Infections in Vivo.

Ni S, Wei H, Li B, Chen F, Liu Y, Chen W, Xu Y, Qiu X, Li X, Lu Y, Liu W, Hu L, Lin D, Wang M, Zheng X, Mao F, Zhu J, Lan L, Li J. Ni S, et al. J Med Chem. 2017 Oct 12;60(19):8145-8159. doi: 10.1021/acs.jmedchem.7b00949. Epub 2017 Sep 21. J Med Chem. 2017. PMID: 28880552

7

Design, Synthesis, and Biological Evaluation of Orally Available First-Generation Dual-Target Selective Inhibitors of Acetylcholinesterase (AChE) and Phosphodiesterase 5 (PDE5) for the Treatment of Alzheimer's Disease.

Mao F, Wang H, Ni W, Zheng X, Wang M, Bao K, Ling D, Li X, Xu Y, Zhang H, Li J. Mao F, et al. ACS Chem Neurosci. 2018 Feb 21;9(2):328-345. doi: 10.1021/acschemneuro.7b00345. Epub 2017 Nov 9. ACS Chem Neurosci. 2018. PMID: 29068218

8

Discovery of novel propargylamine-modified 4-aminoalkyl imidazole substituted pyrimidinylthiourea derivatives as multifunctional agents for the treatment of Alzheimer's disease.

Xu YX, Wang H, Li XK, Dong SN, Liu WW, Gong Q, Wang TD, Tang Y, Zhu J, Li J, Zhang HY, Mao F. Xu YX, et al. Among authors: li xk, li j. Eur J Med Chem. 2018 Jan 1;143:33-47. doi: 10.1016/j.ejmech.2017.08.025. Epub 2017 Aug 10. Eur J Med Chem. 2018. PMID: 29172081

9

Novel Staphyloxanthin Inhibitors with Improved Potency against Multidrug Resistant Staphylococcus aureus.

Ni S, Li B, Chen F, Wei H, Mao F, Liu Y, Xu Y, Qiu X, Li X, Liu W, Hu L, Ling D, Wang M, Zheng X, Zhu J, Lan L, Li J. Ni S, et al. ACS Med Chem Lett. 2018 Feb 22;9(3):233-237. doi: 10.1021/acsmedchemlett.7b00501. eCollection 2018 Mar 8. ACS Med Chem Lett. 2018. PMID: 29541366 Free PMC article.

10

Novel Tadalafil Derivatives Ameliorates Scopolamine-Induced Cognitive Impairment in Mice via Inhibition of Acetylcholinesterase (AChE) and Phosphodiesterase 5 (PDE5).

Ni W, Wang H, Li X, Zheng X, Wang M, Zhang J, Gong Q, Ling D, Mao F, Zhang H, Li J. Ni W, et al. ACS Chem Neurosci. 2018 Jul 18;9(7):1625-1636. doi: 10.1021/acschemneuro.8b00014. Epub 2018 Apr 17. ACS Chem Neurosci. 2018. PMID: 29616790

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