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Inhibition of mast cells: a novel mechanism by which nintedanib may elicit anti-fibrotic effects.
Overed-Sayer C, Miranda E, Dunmore R, Liarte Marin E, Beloki L, Rassl D, Parfrey H, Carruthers A, Chahboub A, Koch S, Güler-Gane G, Kuziora M, Lewis A, Murray L, May R, Clarke D. Overed-Sayer C, et al. Among authors: guler gane g. Thorax. 2020 Sep;75(9):754-763. doi: 10.1136/thoraxjnl-2019-214000. Epub 2020 Jul 24. Thorax. 2020. PMID: 32709610 Free PMC article.
A variant human IgG1-Fc mediates improved ADCC.
Stewart R, Thom G, Levens M, Güler-Gane G, Holgate R, Rudd PM, Webster C, Jermutus L, Lund J. Stewart R, et al. Among authors: guler gane g. Protein Eng Des Sel. 2011 Sep;24(9):671-8. doi: 10.1093/protein/gzr015. Epub 2011 May 18. Protein Eng Des Sel. 2011. PMID: 21596686