Tripathi A - Search Results

1

Rapid Alpha-Synuclein Toxicity in a Neural Cell Model and Its Rescue by a Stearoyl-CoA Desaturase Inhibitor.

Terry-Kantor E, Tripathi A, Imberdis T, LaVoie ZM, Ho GPH, Selkoe D, Fanning S, Ramalingam N, Dettmer U. Terry-Kantor E, et al. Among authors: tripathi a. Int J Mol Sci. 2020 Jul 22;21(15):5193. doi: 10.3390/ijms21155193. Int J Mol Sci. 2020. PMID: 32707907 Free PMC article.

2

Excess membrane binding of monomeric alpha-, beta- and gamma-synuclein is invariably associated with inclusion formation and toxicity.

Kim TE, Newman AJ, Imberdis T, Brontesi L, Tripathi A, Ramalingam N, Fanning S, Selkoe D, Dettmer U. Kim TE, et al. Among authors: tripathi a. Hum Mol Genet. 2021 Nov 16;30(23):2332-2346. doi: 10.1093/hmg/ddab188. Hum Mol Genet. 2021. PMID: 34254125 Free PMC article.

3

Lipotoxicity Downstream of α-Synuclein Imbalance: A Relevant Pathomechanism in Synucleinopathies?

Tripathi A, Fanning S, Dettmer U. Tripathi A, et al. Biomolecules. 2021 Dec 28;12(1):40. doi: 10.3390/biom12010040. Biomolecules. 2021. PMID: 35053188 Free PMC article. Review.

4

Pathogenic Mechanisms of Cytosolic and Membrane-Enriched α-Synuclein Converge on Fatty Acid Homeostasis.

Tripathi A, Alnakhala H, Terry-Kantor E, Newman A, Liu L, Imberdis T, Fanning S, Nuber S, Ramalingam N, Selkoe D, Dettmer U. Tripathi A, et al. J Neurosci. 2022 Mar 9;42(10):2116-2130. doi: 10.1523/JNEUROSCI.1881-21.2022. Epub 2022 Jan 27. J Neurosci. 2022. PMID: 35086904 Free PMC article.

5

5-Nitro-1,2-benzothiazol-3-amine and N-Ethyl-1-[(ethylcarbamoyl)(5-nitro-1,2-benzothiazol-3-yl)amino]formamide Modulate α-Synuclein and Tau Aggregation.

Ramirez E, Ganegamage SK, Elbatrawy AA, Alnakhala H, Shimanaka K, Tripathi A, Min S, Rochet JC, Dettmer U, Fortin JS. Ramirez E, et al. Among authors: tripathi a. ACS Omega. 2023 May 23;8(22):20102-20115. doi: 10.1021/acsomega.3c02668. eCollection 2023 Jun 6. ACS Omega. 2023. PMID: 37305264 Free PMC article.

6

Evaluation of N- and O-Linked Indole Triazines for a Dual Effect on α-Synuclein and Tau Aggregation.

Ramirez E, Ganegamage SK, Min S, Patel H, Ogunware A, Plascencia-Villa G, Alnakhala H, Shimanaka K, Tripathi A, Wang KW, Zhu X, Rochet JC, Kuo MH, Counts SE, Perry G, Dettmer U, Lasagna-Reeves CA, Fortin JS. Ramirez E, et al. Among authors: tripathi a. ACS Chem Neurosci. 2023 Nov 1;14(21):3913-3927. doi: 10.1021/acschemneuro.3c00464. Epub 2023 Oct 11. ACS Chem Neurosci. 2023. PMID: 37818657 Free PMC article.

7

Adding hydrophobicity or positive charges to the cytosolic half of the α-synuclein 3-11 helix increases membrane association and S129 phosphorylation.

Shimanaka K, Shi B, Brontesi L, Alnakhala H, Jayanthi V, Subramanian K, Ramalingam N, Tripathi A, Dettmer U. Shimanaka K, et al. Among authors: tripathi a. FEBS Lett. 2024 Jan;598(2):210-219. doi: 10.1002/1873-3468.14773. Epub 2023 Nov 21. FEBS Lett. 2024. PMID: 37989349 Free PMC article.

8

1,4-Diurea- and 1,4-Dithiourea-Substituted Aromatic Derivatives Selectively Inhibit α-Synuclein Oligomer Formation In Vitro.

Ganegamage SK, Ramirez E, Alnakhala H, Tripathi A, Nguyen CCD, Zami A, Ostafe R, Tian S, Dettmer U, Fortin JS. Ganegamage SK, et al. Among authors: tripathi a. ACS Omega. 2023 Dec 19;9(1):1216-1229. doi: 10.1021/acsomega.3c07453. eCollection 2024 Jan 9. ACS Omega. 2023. PMID: 38222653 Free PMC article.

9

Discovery of small molecule benzothiazole and indole derivatives tackling tau 2N4R and α-synuclein fibrils.

Elbatrawy AA, Ademoye TA, Alnakhala H, Tripathi A, Zami A, Ostafe R, Dettmer U, Fortin JS. Elbatrawy AA, et al. Among authors: tripathi a. Bioorg Med Chem. 2024 Feb 15;100:117613. doi: 10.1016/j.bmc.2024.117613. Epub 2024 Jan 28. Bioorg Med Chem. 2024. PMID: 38330847 Free PMC article.

10

Author Correction: Generation of G51D and 3D mice reveals decreased α-synuclein tetramer-monomer ratios promote Parkinson's disease phenotypes.

Nuber S, Zhang X, McCaffery TD, Moors TE, Adom MA, Hahn WN, Martin D, Ericsson M, Tripathi A, Dettmer U, Svenningsson P, Selkoe DJ. Nuber S, et al. Among authors: tripathi a. NPJ Parkinsons Dis. 2024 Mar 12;10(1):57. doi: 10.1038/s41531-024-00675-5. NPJ Parkinsons Dis. 2024. PMID: 38472218 Free PMC article. No abstract available.

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