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The Jumonji-domain histone demethylase inhibitor JIB-04 deregulates oncogenic programs and increases DNA damage in Ewing Sarcoma, resulting in impaired cell proliferation and survival, and reduced tumor growth.
Parrish JK, McCann TS, Sechler M, Sobral LM, Ren W, Jones KL, Tan AC, Jedlicka P. Parrish JK, et al. Among authors: sobral lm. Oncotarget. 2018 Sep 4;9(69):33110-33123. doi: 10.18632/oncotarget.26011. eCollection 2018 Sep 4. Oncotarget. 2018. PMID: 30237855 Free PMC article.
KDM5A and PHF2 positively control expression of pro-metastatic genes repressed by EWS/Fli1, and promote growth and metastatic properties in Ewing sarcoma.
McCann TS, Parrish JK, Hsieh J, Sechler M, Sobral LM, Self C, Jones KL, Goodspeed A, Costello JC, Jedlicka P. McCann TS, et al. Among authors: sobral lm. Oncotarget. 2020 Oct 27;11(43):3818-3831. doi: 10.18632/oncotarget.27737. eCollection 2020 Oct 27. Oncotarget. 2020. PMID: 33196691 Free PMC article.
Relevance of CCL3/CCR5 axis in oral carcinogenesis.
da Silva JM, Moreira Dos Santos TP, Sobral LM, Queiroz-Junior CM, Rachid MA, Proudfoot AEI, Garlet GP, Batista AC, Teixeira MM, Leopoldino AM, Russo RC, Silva TA. da Silva JM, et al. Among authors: sobral lm. Oncotarget. 2017 Apr 6;8(31):51024-51036. doi: 10.18632/oncotarget.16882. eCollection 2017 Aug 1. Oncotarget. 2017. PMID: 28881626 Free PMC article.
Synergic effect of OP449 and FTY720 on oral squamous cell carcinoma.
Goto RN, Sobral LM, Stringhetta-Padovani K, Garcia CB, da Silva G, Vitek MP, Leopoldino AM. Goto RN, et al. Among authors: sobral lm. Eur J Pharmacol. 2020 Sep 5;882:173268. doi: 10.1016/j.ejphar.2020.173268. Epub 2020 Jun 20. Eur J Pharmacol. 2020. PMID: 32569675 Free article.
Stable SET knockdown in head and neck squamous cell carcinoma promotes cell invasion and the mesenchymal-like phenotype in vitro, as well as necrosis, cisplatin sensitivity and lymph node metastasis in xenograft tumor models.
Sobral LM, Sousa LO, Coletta RD, Cabral H, Greene LJ, Tajara EH, Gutkind JS, Curti C, Leopoldino AM. Sobral LM, et al. Mol Cancer. 2014 Feb 20;13:32. doi: 10.1186/1476-4598-13-32. Mol Cancer. 2014. PMID: 24555657 Free PMC article.
33 results