Leonhardt H - Search Results

1

Distinct and stage-specific contributions of TET1 and TET2 to stepwise cytosine oxidation in the transition from naive to primed pluripotency.

Mulholland CB, Traube FR, Ugur E, Parsa E, Eckl EM, Schönung M, Modic M, Bartoschek MD, Stolz P, Ryan J, Carell T, Leonhardt H, Bultmann S. Mulholland CB, et al. Among authors: leonhardt h. Sci Rep. 2020 Jul 21;10(1):12066. doi: 10.1038/s41598-020-68600-3. Sci Rep. 2020. PMID: 32694513 Free PMC article.

2

DNMT1 but not its interaction with the replication machinery is required for maintenance of DNA methylation in human cells.

Spada F, Haemmer A, Kuch D, Rothbauer U, Schermelleh L, Kremmer E, Carell T, Längst G, Leonhardt H. Spada F, et al. Among authors: leonhardt h. J Cell Biol. 2007 Feb 26;176(5):565-71. doi: 10.1083/jcb.200610062. Epub 2007 Feb 20. J Cell Biol. 2007. PMID: 17312023 Free PMC article.

3

Synthesis of DNA dumbbell based inhibitors for the human DNA methyltransferase Dnmt1.

Kuch D, Schermelleh L, Manetto S, Leonhardt H, Carell T. Kuch D, et al. Among authors: leonhardt h. Angew Chem Int Ed Engl. 2008;47(8):1515-8. doi: 10.1002/anie.200702055. Angew Chem Int Ed Engl. 2008. PMID: 18203234 No abstract available.

4

Np95 interacts with de novo DNA methyltransferases, Dnmt3a and Dnmt3b, and mediates epigenetic silencing of the viral CMV promoter in embryonic stem cells.

Meilinger D, Fellinger K, Bultmann S, Rothbauer U, Bonapace IM, Klinkert WE, Spada F, Leonhardt H. Meilinger D, et al. Among authors: leonhardt h. EMBO Rep. 2009 Nov;10(11):1259-64. doi: 10.1038/embor.2009.201. Epub 2009 Oct 2. EMBO Rep. 2009. PMID: 19798101 Free PMC article.

5

Sensitive enzymatic quantification of 5-hydroxymethylcytosine in genomic DNA.

Szwagierczak A, Bultmann S, Schmidt CS, Spada F, Leonhardt H. Szwagierczak A, et al. Among authors: leonhardt h. Nucleic Acids Res. 2010 Oct;38(19):e181. doi: 10.1093/nar/gkq684. Epub 2010 Aug 4. Nucleic Acids Res. 2010. PMID: 20685817 Free PMC article.

6

Different binding properties and function of CXXC zinc finger domains in Dnmt1 and Tet1.

Frauer C, Rottach A, Meilinger D, Bultmann S, Fellinger K, Hasenöder S, Wang M, Qin W, Söding J, Spada F, Leonhardt H. Frauer C, et al. Among authors: leonhardt h. PLoS One. 2011 Feb 2;6(2):e16627. doi: 10.1371/journal.pone.0016627. PLoS One. 2011. PMID: 21311766 Free PMC article.

7

Characterization of PvuRts1I endonuclease as a tool to investigate genomic 5-hydroxymethylcytosine.

Szwagierczak A, Brachmann A, Schmidt CS, Bultmann S, Leonhardt H, Spada F. Szwagierczak A, et al. Among authors: leonhardt h. Nucleic Acids Res. 2011 Jul;39(12):5149-56. doi: 10.1093/nar/gkr118. Epub 2011 Mar 4. Nucleic Acids Res. 2011. PMID: 21378122 Free PMC article.

8

Recognition of 5-hydroxymethylcytosine by the Uhrf1 SRA domain.

Frauer C, Hoffmann T, Bultmann S, Casa V, Cardoso MC, Antes I, Leonhardt H. Frauer C, et al. Among authors: leonhardt h. PLoS One. 2011;6(6):e21306. doi: 10.1371/journal.pone.0021306. Epub 2011 Jun 22. PLoS One. 2011. PMID: 21731699 Free PMC article.

9

Targeted transcriptional activation of silent oct4 pluripotency gene by combining designer TALEs and inhibition of epigenetic modifiers.

Bultmann S, Morbitzer R, Schmidt CS, Thanisch K, Spada F, Elsaesser J, Lahaye T, Leonhardt H. Bultmann S, et al. Among authors: leonhardt h. Nucleic Acids Res. 2012 Jul;40(12):5368-77. doi: 10.1093/nar/gks199. Epub 2012 Mar 2. Nucleic Acids Res. 2012. PMID: 22387464 Free PMC article.

10

Global DNA hypomethylation prevents consolidation of differentiation programs and allows reversion to the embryonic stem cell state.

Schmidt CS, Bultmann S, Meilinger D, Zacher B, Tresch A, Maier KC, Peter C, Martin DE, Leonhardt H, Spada F. Schmidt CS, et al. Among authors: leonhardt h. PLoS One. 2012;7(12):e52629. doi: 10.1371/journal.pone.0052629. Epub 2012 Dec 27. PLoS One. 2012. PMID: 23300728 Free PMC article.

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