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Chlorine substituents and linker topology as factors of 5-HT6R activity for novel highly active 1,3,5-triazine derivatives with procognitive properties in vivo.
Sudoł S, Kucwaj-Brysz K, Kurczab R, Wilczyńska N, Jastrzębska-Więsek M, Satała G, Latacz G, Głuch-Lutwin M, Mordyl B, Żesławska E, Nitek W, Partyka A, Buzun K, Doroz-Płonka A, Wesołowska A, Bielawska A, Handzlik J. Sudoł S, et al. Eur J Med Chem. 2020 Oct 1;203:112529. doi: 10.1016/j.ejmech.2020.112529. Epub 2020 Jul 6. Eur J Med Chem. 2020. PMID: 32693296 Free article.
Similarities and differences in affinity and binding modes of tricyclic pyrimido- and pyrazinoxanthines at human and rat adenosine receptors.
Szymańska E, Drabczyńska A, Karcz T, Müller CE, Köse M, Karolak-Wojciechowska J, Fruziński A, Schabikowski J, Doroz-Płonka A, Handzlik J, Kieć-Kononowicz K. Szymańska E, et al. Bioorg Med Chem. 2016 Sep 15;24(18):4347-4362. doi: 10.1016/j.bmc.2016.07.028. Epub 2016 Jul 18. Bioorg Med Chem. 2016. PMID: 27485602
Are the Hydantoin-1,3,5-triazine 5-HT6R Ligands a Hope to a Find New Procognitive and Anti-Obesity Drug? Considerations Based on Primary In Vivo Assays and ADME-Tox Profile In Vitro.
Lubelska A, Latacz G, Jastrzębska-Więsek M, Kotańska M, Kurczab R, Partyka A, Marć MA, Wilczyńska D, Doroz-Płonka A, Łażewska D, Wesołowska A, Kieć-Kononowicz K, Handzlik J. Lubelska A, et al. Molecules. 2019 Dec 6;24(24):4472. doi: 10.3390/molecules24244472. Molecules. 2019. PMID: 31817628 Free PMC article.
Rational design of new multitarget histamine H3 receptor ligands as potential candidates for treatment of Alzheimer's disease.
Łażewska D, Bajda M, Kaleta M, Zaręba P, Doroz-Płonka A, Siwek A, Alachkar A, Mogilski S, Saad A, Kuder K, Olejarz-Maciej A, Godyń J, Stary D, Sudoł S, Więcek M, Latacz G, Walczak M, Handzlik J, Sadek B, Malawska B, Kieć-Kononowicz K. Łażewska D, et al. Eur J Med Chem. 2020 Dec 1;207:112743. doi: 10.1016/j.ejmech.2020.112743. Epub 2020 Aug 21. Eur J Med Chem. 2020. PMID: 32882609
Molecular Insights into an Antibiotic Enhancer Action of New Morpholine-Containing 5-Arylideneimidazolones in the Fight against MDR Bacteria.
Kaczor A, Witek K, Podlewska S, Sinou V, Czekajewska J, Żesławska E, Doroz-Płonka A, Lubelska A, Latacz G, Nitek W, Bischoff M, Alibert S, Pagès JM, Jacob C, Karczewska E, Bolla JM, Handzlik J. Kaczor A, et al. Int J Mol Sci. 2021 Feb 19;22(4):2062. doi: 10.3390/ijms22042062. Int J Mol Sci. 2021. PMID: 33669790 Free PMC article.
Cyanobiphenyls: Novel H3 receptor ligands with cholinesterase and MAO B inhibitory activity as multitarget compounds for potential treatment of Alzheimer's disease.
Godyń J, Zaręba P, Łażewska D, Stary D, Reiner-Link D, Frank A, Latacz G, Mogilski S, Kaleta M, Doroz-Płonka A, Lubelska A, Honkisz-Orzechowska E, Olejarz-Maciej A, Handzlik J, Stark H, Kieć-Kononowicz K, Malawska B, Bajda M. Godyń J, et al. Among authors: doroz plonka a. Bioorg Chem. 2021 Sep;114:105129. doi: 10.1016/j.bioorg.2021.105129. Epub 2021 Jun 28. Bioorg Chem. 2021. PMID: 34217977 Free article.
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