Schiffer CA - Search Results

1

Structural Analysis of Potent Hybrid HIV-1 Protease Inhibitors Containing Bis-tetrahydrofuran in a Pseudosymmetric Dipeptide Isostere.

Rusere LN, Lockbaum GJ, Henes M, Lee SK, Spielvogel E, Rao DN, Kosovrasti K, Nalivaika EA, Swanstrom R, Kurt Yilmaz N, Schiffer CA, Ali A. Rusere LN, et al. Among authors: schiffer ca. J Med Chem. 2020 Aug 13;63(15):8296-8313. doi: 10.1021/acs.jmedchem.0c00529. Epub 2020 Aug 3. J Med Chem. 2020. PMID: 32672965 Free PMC article.

2

How does a symmetric dimer recognize an asymmetric substrate? A substrate complex of HIV-1 protease.

Prabu-Jeyabalan M, Nalivaika E, Schiffer CA. Prabu-Jeyabalan M, et al. Among authors: schiffer ca. J Mol Biol. 2000 Sep 1;301(5):1207-20. doi: 10.1006/jmbi.2000.4018. J Mol Biol. 2000. PMID: 10966816

3

Lack of synergy for inhibitors targeting a multi-drug-resistant HIV-1 protease.

King NM, Melnick L, Prabu-Jeyabalan M, Nalivaika EA, Yang SS, Gao Y, Nie X, Zepp C, Heefner DL, Schiffer CA. King NM, et al. Among authors: schiffer ca. Protein Sci. 2002 Feb;11(2):418-29. doi: 10.1110/ps.25502. Protein Sci. 2002. PMID: 11790852 Free PMC article.

4

Substrate shape determines specificity of recognition for HIV-1 protease: analysis of crystal structures of six substrate complexes.

Prabu-Jeyabalan M, Nalivaika E, Schiffer CA. Prabu-Jeyabalan M, et al. Among authors: schiffer ca. Structure. 2002 Mar;10(3):369-81. doi: 10.1016/s0969-2126(02)00720-7. Structure. 2002. PMID: 12005435 Free article.

5

Replacement of the P1 amino acid of human immunodeficiency virus type 1 Gag processing sites can inhibit or enhance the rate of cleavage by the viral protease.

Pettit SC, Henderson GJ, Schiffer CA, Swanstrom R. Pettit SC, et al. Among authors: schiffer ca. J Virol. 2002 Oct;76(20):10226-33. doi: 10.1128/jvi.76.20.10226-10233.2002. J Virol. 2002. PMID: 12239298 Free PMC article.

6

Viability of a drug-resistant human immunodeficiency virus type 1 protease variant: structural insights for better antiviral therapy.

Prabu-Jeyabalan M, Nalivaika EA, King NM, Schiffer CA. Prabu-Jeyabalan M, et al. Among authors: schiffer ca. J Virol. 2003 Jan;77(2):1306-15. doi: 10.1128/jvi.77.2.1306-1315.2003. J Virol. 2003. PMID: 12502847 Free PMC article.

7

Covariation of amino acid positions in HIV-1 protease.

Hoffman NG, Schiffer CA, Swanstrom R. Hoffman NG, et al. Among authors: schiffer ca. Virology. 2003 Sep 30;314(2):536-48. doi: 10.1016/s0042-6822(03)00484-7. Virology. 2003. PMID: 14554082 Free article.

8

Structural and thermodynamic basis for the binding of TMC114, a next-generation human immunodeficiency virus type 1 protease inhibitor.

King NM, Prabu-Jeyabalan M, Nalivaika EA, Wigerinck P, de Béthune MP, Schiffer CA. King NM, et al. Among authors: schiffer ca. J Virol. 2004 Nov;78(21):12012-21. doi: 10.1128/JVI.78.21.12012-12021.2004. J Virol. 2004. PMID: 15479840 Free PMC article.

9

Combating susceptibility to drug resistance: lessons from HIV-1 protease.

King NM, Prabu-Jeyabalan M, Nalivaika EA, Schiffer CA. King NM, et al. Among authors: schiffer ca. Chem Biol. 2004 Oct;11(10):1333-8. doi: 10.1016/j.chembiol.2004.08.010. Chem Biol. 2004. PMID: 15489160

10

Structural basis for coevolution of a human immunodeficiency virus type 1 nucleocapsid-p1 cleavage site with a V82A drug-resistant mutation in viral protease.

Prabu-Jeyabalan M, Nalivaika EA, King NM, Schiffer CA. Prabu-Jeyabalan M, et al. Among authors: schiffer ca. J Virol. 2004 Nov;78(22):12446-54. doi: 10.1128/JVI.78.22.12446-12454.2004. J Virol. 2004. PMID: 15507631 Free PMC article.

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