Lee SK - Search Results

1

Structural Analysis of Potent Hybrid HIV-1 Protease Inhibitors Containing Bis-tetrahydrofuran in a Pseudosymmetric Dipeptide Isostere.

Rusere LN, Lockbaum GJ, Henes M, Lee SK, Spielvogel E, Rao DN, Kosovrasti K, Nalivaika EA, Swanstrom R, Kurt Yilmaz N, Schiffer CA, Ali A. Rusere LN, et al. Among authors: lee sk. J Med Chem. 2020 Aug 13;63(15):8296-8313. doi: 10.1021/acs.jmedchem.0c00529. Epub 2020 Aug 3. J Med Chem. 2020. PMID: 32672965 Free PMC article.

2

Viral protease inhibitors.

Anderson J, Schiffer C, Lee SK, Swanstrom R. Anderson J, et al. Among authors: lee sk. Handb Exp Pharmacol. 2009;189(189):85-110. doi: 10.1007/978-3-540-79086-0_4. Handb Exp Pharmacol. 2009. PMID: 19048198 Free PMC article. Review.

3

A strongly transdominant mutation in the human immunodeficiency virus type 1 gag gene defines an Achilles heel in the virus life cycle.

Lee SK, Harris J, Swanstrom R. Lee SK, et al. J Virol. 2009 Sep;83(17):8536-43. doi: 10.1128/JVI.00317-09. Epub 2009 Jun 10. J Virol. 2009. PMID: 19515760 Free PMC article.

4

Interplay between single resistance-associated mutations in the HIV-1 protease and viral infectivity, protease activity, and inhibitor sensitivity.

Henderson GJ, Lee SK, Irlbeck DM, Harris J, Kline M, Pollom E, Parkin N, Swanstrom R. Henderson GJ, et al. Among authors: lee sk. Antimicrob Agents Chemother. 2012 Feb;56(2):623-33. doi: 10.1128/AAC.05549-11. Epub 2011 Nov 14. Antimicrob Agents Chemother. 2012. PMID: 22083488 Free PMC article.

5

Context surrounding processing sites is crucial in determining cleavage rate of a subset of processing sites in HIV-1 Gag and Gag-Pro-Pol polyprotein precursors by viral protease.

Lee SK, Potempa M, Kolli M, Özen A, Schiffer CA, Swanstrom R. Lee SK, et al. J Biol Chem. 2012 Apr 13;287(16):13279-90. doi: 10.1074/jbc.M112.339374. Epub 2012 Feb 13. J Biol Chem. 2012. PMID: 22334652 Free PMC article.

6

The choreography of HIV-1 proteolytic processing and virion assembly.

Lee SK, Potempa M, Swanstrom R. Lee SK, et al. J Biol Chem. 2012 Nov 30;287(49):40867-74. doi: 10.1074/jbc.R112.399444. Epub 2012 Oct 5. J Biol Chem. 2012. PMID: 23043111 Free PMC article. Review.

7

A sensitive assay using a native protein substrate for screening HIV-1 maturation inhibitors targeting the protease cleavage site between the matrix and capsid.

Lee SK, Cheng N, Hull-Ryde E, Potempa M, Schiffer CA, Janzen W, Swanstrom R. Lee SK, et al. Biochemistry. 2013 Jul 23;52(29):4929-40. doi: 10.1021/bi4005232. Epub 2013 Jul 11. Biochemistry. 2013. PMID: 23763575 Free PMC article.

8

Development of a Novel Screening Strategy Designed to Discover a New Class of HIV Drugs.

Cheng N, Lee SK, Donover PS, Reichman M, Schiffer CA, Hull-Ryde EA, Swanstrom R, Janzen WP. Cheng N, et al. Among authors: lee sk. J Lab Autom. 2014 Jun;19(3):297-303. doi: 10.1177/2211068213513453. Epub 2013 Dec 4. J Lab Autom. 2014. PMID: 24305957 Free PMC article.

9

The triple threat of HIV-1 protease inhibitors.

Potempa M, Lee SK, Wolfenden R, Swanstrom R. Potempa M, et al. Among authors: lee sk. Curr Top Microbiol Immunol. 2015;389:203-41. doi: 10.1007/82_2015_438. Curr Top Microbiol Immunol. 2015. PMID: 25778681 Review.

10

A Direct Interaction with RNA Dramatically Enhances the Catalytic Activity of the HIV-1 Protease In Vitro.

Potempa M, Nalivaika E, Ragland D, Lee SK, Schiffer CA, Swanstrom R. Potempa M, et al. Among authors: lee sk. J Mol Biol. 2015 Jul 17;427(14):2360-78. doi: 10.1016/j.jmb.2015.05.007. Epub 2015 May 15. J Mol Biol. 2015. PMID: 25986307 Free PMC article.

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