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A cytotoxic agent can be generated selectively at cancer sites.
Bagshawe KD, Springer CJ, Searle F, Antoniw P, Sharma SK, Melton RG, Sherwood RF. Bagshawe KD, et al. Among authors: sherwood rf. Br J Cancer. 1988 Dec;58(6):700-3. doi: 10.1038/bjc.1988.293. Br J Cancer. 1988. PMID: 3265633 Free PMC article.
The potential of carboxypeptidase G2-antibody conjugates as anti-tumour agents. I. Preparation of antihuman chorionic gonadotrophin-carboxypeptidase G2 and cytotoxicity of the conjugate against JAR choriocarcinoma cells in vitro.
Searle F, Bier C, Buckley RG, Newman S, Pedley RB, Bagshawe KD, Melton RG, Alwan SM, Sherwood RF. Searle F, et al. Among authors: sherwood rf. Br J Cancer. 1986 Mar;53(3):377-84. doi: 10.1038/bjc.1986.62. Br J Cancer. 1986. PMID: 3964540 Free PMC article.
Antibody directed enzyme prodrug therapy (ADEPT): clinical report.
Bagshawe KD, Sharma SK, Springer CJ, Antoniw P, Boden JA, Rogers GT, Burke PJ, Melton RG, Sherwood RF. Bagshawe KD, et al. Among authors: sherwood rf. Dis Markers. 1991 May-Aug;9(3-4):233-8. Dis Markers. 1991. PMID: 1813213 Clinical Trial.
Antibody-enzyme conjugates for cancer therapy.
Melton RG, Sherwood RF. Melton RG, et al. Among authors: sherwood rf. J Natl Cancer Inst. 1996 Feb 21;88(3-4):153-65. doi: 10.1093/jnci/88.3-4.153. J Natl Cancer Inst. 1996. PMID: 8632489 Review.
41 results