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Page 1
A Brain-Permeable Aminosterol Regulates Cell Membranes to Mitigate the Toxicity of Diverse Pore-Forming Agents.
Kreiser RP, Wright AK, Sasser LR, Rinauro DJ, Gabriel JM, Hsu CM, Hurtado JA, McKenzie TL, Errico S, Albright JA, Richardson L, Jaffett VA, Riegner DE, Nguyen LT, LeForte K, Zasloff M, Hollows JE, Chiti F, Vendruscolo M, Limbocker R. Kreiser RP, et al. ACS Chem Neurosci. 2022 Apr 20;13(8):1219-1231. doi: 10.1021/acschemneuro.1c00840. Epub 2022 Apr 11. ACS Chem Neurosci. 2022. PMID: 35404569 Free PMC article.
Squalamine and Its Derivatives Modulate the Aggregation of Amyloid-β and α-Synuclein and Suppress the Toxicity of Their Oligomers.
Limbocker R, Staats R, Chia S, Ruggeri FS, Mannini B, Xu CK, Perni M, Cascella R, Bigi A, Sasser LR, Block NR, Wright AK, Kreiser RP, Custy ET, Meisl G, Errico S, Habchi J, Flagmeier P, Kartanas T, Hollows JE, Nguyen LT, LeForte K, Barbut D, Kumita JR, Cecchi C, Zasloff M, Knowles TPJ, Dobson CM, Chiti F, Vendruscolo M. Limbocker R, et al. Among authors: kreiser rp. Front Neurosci. 2021 Jun 18;15:680026. doi: 10.3389/fnins.2021.680026. eCollection 2021. Front Neurosci. 2021. PMID: 34220435 Free PMC article.
Trodusquemine displaces protein misfolded oligomers from cell membranes and abrogates their cytotoxicity through a generic mechanism.
Limbocker R, Mannini B, Ruggeri FS, Cascella R, Xu CK, Perni M, Chia S, Chen SW, Habchi J, Bigi A, Kreiser RP, Wright AK, Albright JA, Kartanas T, Kumita JR, Cremades N, Zasloff M, Cecchi C, Knowles TPJ, Chiti F, Vendruscolo M, Dobson CM. Limbocker R, et al. Among authors: kreiser rp. Commun Biol. 2020 Aug 13;3(1):435. doi: 10.1038/s42003-020-01140-8. Commun Biol. 2020. PMID: 32792544 Free PMC article.
Rationally Designed Antibodies as Research Tools to Study the Structure-Toxicity Relationship of Amyloid-β Oligomers.
Limbocker R, Mannini B, Cataldi R, Chhangur S, Wright AK, Kreiser RP, Albright JA, Chia S, Habchi J, Sormanni P, Kumita JR, Ruggeri FS, Dobson CM, Chiti F, Aprile FA, Vendruscolo M. Limbocker R, et al. Among authors: kreiser rp. Int J Mol Sci. 2020 Jun 25;21(12):4542. doi: 10.3390/ijms21124542. Int J Mol Sci. 2020. PMID: 32630615 Free PMC article.