Knowles PP - Search Results

1

Improved antitumor effects of immunotoxins prepared with deglycosylated ricin A-chain and hindered disulfide linkages.

Thorpe PE, Wallace PM, Knowles PP, Relf MG, Brown AN, Watson GJ, Blakey DC, Newell DR. Thorpe PE, et al. Among authors: knowles pp. Cancer Res. 1988 Nov 15;48(22):6396-403. Cancer Res. 1988. PMID: 3263186

2

Evaluation of ricin A chain-containing immunotoxins directed against CD19 and CD22 antigens on normal and malignant human B-cells as potential reagents for in vivo therapy.

Ghetie MA, May RD, Till M, Uhr JW, Ghetie V, Knowles PP, Relf M, Brown A, Wallace PM, Janossy G, et al. Ghetie MA, et al. Among authors: knowles pp. Cancer Res. 1988 May 1;48(9):2610-7. Cancer Res. 1988. PMID: 2451562 Clinical Trial.

3

Comparison of two anti-Thy 1.1-abrin A-chain immunotoxins prepared with different cross-linking agents: antitumor effects, in vivo fate, and tumor cell mutants.

Thorpe PE, Blakey DC, Brown AN, Knowles PP, Knyba RE, Wallace PM, Watson GJ, Wawrzynczak EJ. Thorpe PE, et al. Among authors: knowles pp. J Natl Cancer Inst. 1987 Nov;79(5):1101-12. J Natl Cancer Inst. 1987. PMID: 2890786

4

Effect of chemical deglycosylation of ricin A chain on the in vivo fate and cytotoxic activity of an immunotoxin composed of ricin A chain and anti-Thy 1.1 antibody.

Blakey DC, Watson GJ, Knowles PP, Thorpe PE. Blakey DC, et al. Among authors: knowles pp. Cancer Res. 1987 Feb 15;47(4):947-52. Cancer Res. 1987. PMID: 3492271

5

New coupling agents for the synthesis of immunotoxins containing a hindered disulfide bond with improved stability in vivo.

Thorpe PE, Wallace PM, Knowles PP, Relf MG, Brown AN, Watson GJ, Knyba RE, Wawrzynczak EJ, Blakey DC. Thorpe PE, et al. Among authors: knowles pp. Cancer Res. 1987 Nov 15;47(22):5924-31. Cancer Res. 1987. PMID: 3499221

6

Purification of immunotoxins containing ricin A-chain and abrin A-chain using blue sepharose CL-6B.

Knowles PP, Thorpe PE. Knowles PP, et al. Anal Biochem. 1987 Feb 1;160(2):440-3. doi: 10.1016/0003-2697(87)90073-x. Anal Biochem. 1987. PMID: 3495199

7

Heparin-steroid conjugates: new angiogenesis inhibitors with antitumor activity in mice.

Thorpe PE, Derbyshire EJ, Andrade SP, Press N, Knowles PP, King S, Watson GJ, Yang YC, Rao-Betté M. Thorpe PE, et al. Among authors: knowles pp. Cancer Res. 1993 Jul 1;53(13):3000-7. Cancer Res. 1993. PMID: 7686447

8

Evaluation of four CD22 antibodies as ricin A chain-containing immunotoxins for the in vivo therapy of human B-cell leukemias and lymphomas.

Shen GL, Li JL, Ghetie MA, Ghetie V, May RD, Till M, Brown AN, Relf M, Knowles P, Uhr JW, et al. Shen GL, et al. Int J Cancer. 1988 Nov 15;42(5):792-7. doi: 10.1002/ijc.2910420527. Int J Cancer. 1988. PMID: 3263328

9

Purification of ricin A1, A2, and B chains and characterization of their toxicity.

Fulton RJ, Blakey DC, Knowles PP, Uhr JW, Thorpe PE, Vitetta ES. Fulton RJ, et al. Among authors: knowles pp. J Biol Chem. 1986 Apr 25;261(12):5314-9. J Biol Chem. 1986. PMID: 3957927 Free article.

10

The GLP large scale preparation of immunotoxins containing deglycosylated ricin A chain and a hindered disulfide bond.

Ghetie V, Thorpe P, Ghetie MA, Knowles P, Uhr JW, Vitetta ES. Ghetie V, et al. J Immunol Methods. 1991 Sep 13;142(2):223-30. doi: 10.1016/0022-1759(91)90110-2. J Immunol Methods. 1991. PMID: 1717600

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