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Extensive sequence and structural evolution of Arginase 2 inhibitory antibodies enabled by an unbiased approach to affinity maturation.
Chan DTY, Jenkinson L, Haynes SW, Austin M, Diamandakis A, Burschowsky D, Seewooruthun C, Addyman A, Fiedler S, Ryman S, Whitehouse J, Slater LH, Gowans E, Shibata Y, Barnard M, Wilkinson RW, Vaughan TJ, Holt SV, Cerundolo V, Carr MD, Groves MAT. Chan DTY, et al. Among authors: cerundolo v. Proc Natl Acad Sci U S A. 2020 Jul 21;117(29):16949-16960. doi: 10.1073/pnas.1919565117. Epub 2020 Jul 2. Proc Natl Acad Sci U S A. 2020. PMID: 32616569 Free PMC article.
Rational development of high-affinity T-cell receptor-like antibodies.
Stewart-Jones G, Wadle A, Hombach A, Shenderov E, Held G, Fischer E, Kleber S, Nuber N, Stenner-Liewen F, Bauer S, McMichael A, Knuth A, Abken H, Hombach AA, Cerundolo V, Jones EY, Renner C. Stewart-Jones G, et al. Among authors: cerundolo v. Proc Natl Acad Sci U S A. 2009 Apr 7;106(14):5784-8. doi: 10.1073/pnas.0901425106. Epub 2009 Mar 23. Proc Natl Acad Sci U S A. 2009. PMID: 19307587 Free PMC article.
Structural and functional characterization of C0021158, a high-affinity monoclonal antibody that inhibits Arginase 2 function via a novel non-competitive mechanism of action.
Austin M, Burschowsky D, Chan DTY, Jenkinson L, Haynes S, Diamandakis A, Seewooruthun C, Addyman A, Fiedler S, Ryman S, Whitehouse J, Slater LH, Hadjinicolaou AV, Gileadi U, Gowans E, Shibata Y, Barnard M, Kaserer T, Sharma P, Luheshi NM, Wilkinson RW, Vaughan TJ, Holt SV, Cerundolo V, Carr MD, Groves MAT. Austin M, et al. Among authors: cerundolo v. MAbs. 2020 Jan-Dec;12(1):1801230. doi: 10.1080/19420862.2020.1801230. MAbs. 2020. PMID: 32880207 Free PMC article.
Human CD1d-glycolipid tetramers generated by in vitro oxidative refolding chromatography.
Karadimitris A, Gadola S, Altamirano M, Brown D, Woolfson A, Klenerman P, Chen JL, Koezuka Y, Roberts IA, Price DA, Dusheiko G, Milstein C, Fersht A, Luzzatto L, Cerundolo V. Karadimitris A, et al. Among authors: cerundolo v. Proc Natl Acad Sci U S A. 2001 Mar 13;98(6):3294-8. doi: 10.1073/pnas.051604498. Proc Natl Acad Sci U S A. 2001. PMID: 11248072 Free PMC article.
BCL6b mediates the enhanced magnitude of the secondary response of memory CD8+ T lymphocytes.
Manders PM, Hunter PJ, Telaranta AI, Carr JM, Marshall JL, Carrasco M, Murakami Y, Palmowski MJ, Cerundolo V, Kaech SM, Ahmed R, Fearon DT. Manders PM, et al. Among authors: cerundolo v. Proc Natl Acad Sci U S A. 2005 May 24;102(21):7418-25. doi: 10.1073/pnas.0501585102. Epub 2005 Apr 15. Proc Natl Acad Sci U S A. 2005. PMID: 15833813 Free PMC article.
Implications for invariant natural killer T cell ligands due to the restricted presence of isoglobotrihexosylceramide in mammals.
Speak AO, Salio M, Neville DC, Fontaine J, Priestman DA, Platt N, Heare T, Butters TD, Dwek RA, Trottein F, Exley MA, Cerundolo V, Platt FM. Speak AO, et al. Among authors: cerundolo v. Proc Natl Acad Sci U S A. 2007 Apr 3;104(14):5971-6. doi: 10.1073/pnas.0607285104. Epub 2007 Mar 19. Proc Natl Acad Sci U S A. 2007. PMID: 17372214 Free PMC article.
Saposins modulate human invariant Natural Killer T cells self-reactivity and facilitate lipid exchange with CD1d molecules during antigen presentation.
Salio M, Ghadbane H, Dushek O, Shepherd D, Cypen J, Gileadi U, Aichinger MC, Napolitani G, Qi X, van der Merwe PA, Wojno J, Veerapen N, Cox LR, Besra GS, Yuan W, Cresswell P, Cerundolo V. Salio M, et al. Among authors: cerundolo v. Proc Natl Acad Sci U S A. 2013 Dec 3;110(49):E4753-61. doi: 10.1073/pnas.1310050110. Epub 2013 Nov 18. Proc Natl Acad Sci U S A. 2013. PMID: 24248359 Free PMC article.
320 results