Mootha VK - Search Results

1

An essential role for cardiolipin in the stability and function of the mitochondrial calcium uniporter.

Ghosh S, Basu Ball W, Madaris TR, Srikantan S, Madesh M, Mootha VK, Gohil VM. Ghosh S, et al. Among authors: mootha vk. Proc Natl Acad Sci U S A. 2020 Jul 14;117(28):16383-16390. doi: 10.1073/pnas.2000640117. Epub 2020 Jun 29. Proc Natl Acad Sci U S A. 2020. PMID: 32601238 Free PMC article.

2

A computational screen for regulators of oxidative phosphorylation implicates SLIRP in mitochondrial RNA homeostasis.

Baughman JM, Nilsson R, Gohil VM, Arlow DH, Gauhar Z, Mootha VK. Baughman JM, et al. Among authors: mootha vk. PLoS Genet. 2009 Aug;5(8):e1000590. doi: 10.1371/journal.pgen.1000590. Epub 2009 Aug 14. PLoS Genet. 2009. PMID: 19680543 Free PMC article.

3

A plasma signature of human mitochondrial disease revealed through metabolic profiling of spent media from cultured muscle cells.

Shaham O, Slate NG, Goldberger O, Xu Q, Ramanathan A, Souza AL, Clish CB, Sims KB, Mootha VK. Shaham O, et al. Among authors: mootha vk. Proc Natl Acad Sci U S A. 2010 Jan 26;107(4):1571-5. doi: 10.1073/pnas.0906039107. Epub 2010 Jan 8. Proc Natl Acad Sci U S A. 2010. PMID: 20080599 Free PMC article.

4

Nutrient-sensitized screening for drugs that shift energy metabolism from mitochondrial respiration to glycolysis.

Gohil VM, Sheth SA, Nilsson R, Wojtovich AP, Lee JH, Perocchi F, Chen W, Clish CB, Ayata C, Brookes PS, Mootha VK. Gohil VM, et al. Among authors: mootha vk. Nat Biotechnol. 2010 Mar;28(3):249-55. doi: 10.1038/nbt.1606. Epub 2010 Feb 14. Nat Biotechnol. 2010. PMID: 20160716 Free PMC article.

5

Mitochondrial and nuclear genomic responses to loss of LRPPRC expression.

Gohil VM, Nilsson R, Belcher-Timme CA, Luo B, Root DE, Mootha VK. Gohil VM, et al. Among authors: mootha vk. J Biol Chem. 2010 Apr 30;285(18):13742-7. doi: 10.1074/jbc.M109.098400. Epub 2010 Mar 10. J Biol Chem. 2010. PMID: 20220140 Free PMC article.

6

MICU1 encodes a mitochondrial EF hand protein required for Ca(2+) uptake.

Perocchi F, Gohil VM, Girgis HS, Bao XR, McCombs JE, Palmer AE, Mootha VK. Perocchi F, et al. Among authors: mootha vk. Nature. 2010 Sep 16;467(7313):291-6. doi: 10.1038/nature09358. Epub 2010 Aug 8. Nature. 2010. PMID: 20693986 Free PMC article.

7

Meclizine is neuroprotective in models of Huntington's disease.

Gohil VM, Offner N, Walker JA, Sheth SA, Fossale E, Gusella JF, MacDonald ME, Neri C, Mootha VK. Gohil VM, et al. Among authors: mootha vk. Hum Mol Genet. 2011 Jan 15;20(2):294-300. doi: 10.1093/hmg/ddq464. Epub 2010 Oct 25. Hum Mol Genet. 2011. PMID: 20977989 Free PMC article.

8

Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter.

Baughman JM, Perocchi F, Girgis HS, Plovanich M, Belcher-Timme CA, Sancak Y, Bao XR, Strittmatter L, Goldberger O, Bogorad RL, Koteliansky V, Mootha VK. Baughman JM, et al. Among authors: mootha vk. Nature. 2011 Jun 19;476(7360):341-5. doi: 10.1038/nature10234. Nature. 2011. PMID: 21685886 Free PMC article.

9

Evolutionary diversity of the mitochondrial calcium uniporter.

Bick AG, Calvo SE, Mootha VK. Bick AG, et al. Among authors: mootha vk. Science. 2012 May 18;336(6083):886. doi: 10.1126/science.1214977. Science. 2012. PMID: 22605770 Free PMC article.

10

MICU2, a paralog of MICU1, resides within the mitochondrial uniporter complex to regulate calcium handling.

Plovanich M, Bogorad RL, Sancak Y, Kamer KJ, Strittmatter L, Li AA, Girgis HS, Kuchimanchi S, De Groot J, Speciner L, Taneja N, Oshea J, Koteliansky V, Mootha VK. Plovanich M, et al. Among authors: mootha vk. PLoS One. 2013;8(2):e55785. doi: 10.1371/journal.pone.0055785. Epub 2013 Feb 7. PLoS One. 2013. PMID: 23409044 Free PMC article.

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