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A New Potent and Selective Monoamine Oxidase-B Inhibitor with Extended Conjugation in a Chalcone Framework: 1-[4-(Morpholin-4-yl)phenyl]-5-phenylpenta-2,4-dien-1-one.
Maliyakkal N, Eom BH, Heo JH, Abdullah Almoyad MA, Thomas Parambi DG, Gambacorta N, Nicolotti O, Beeran AA, Kim H, Mathew B. Maliyakkal N, et al. Among authors: nicolotti o. ChemMedChem. 2020 Sep 3;15(17):1629-1633. doi: 10.1002/cmdc.202000305. Epub 2020 Jul 15. ChemMedChem. 2020. PMID: 32583952
Discovery of a novel class of potent coumarin monoamine oxidase B inhibitors: development and biopharmacological profiling of 7-[(3-chlorobenzyl)oxy]-4-[(methylamino)methyl]-2H-chromen-2-one methanesulfonate (NW-1772) as a highly potent, selective, reversible, and orally active monoamine oxidase B inhibitor.
Pisani L, Muncipinto G, Miscioscia TF, Nicolotti O, Leonetti F, Catto M, Caccia C, Salvati P, Soto-Otero R, Mendez-Alvarez E, Passeleu C, Carotti A. Pisani L, et al. Among authors: nicolotti o. J Med Chem. 2009 Nov 12;52(21):6685-706. doi: 10.1021/jm9010127. J Med Chem. 2009. PMID: 19810674
Discovery, biological evaluation, and structure-activity and -selectivity relationships of 6'-substituted (E)-2-(benzofuran-3(2H)-ylidene)-N-methylacetamides, a novel class of potent and selective monoamine oxidase inhibitors.
Pisani L, Barletta M, Soto-Otero R, Nicolotti O, Mendez-Alvarez E, Catto M, Introcaso A, Stefanachi A, Cellamare S, Altomare C, Carotti A. Pisani L, et al. Among authors: nicolotti o. J Med Chem. 2013 Mar 28;56(6):2651-64. doi: 10.1021/jm4000769. Epub 2013 Mar 13. J Med Chem. 2013. PMID: 23437843
Discovery of new 7-substituted-4-imidazolylmethyl coumarins and 4'-substituted-2-imidazolyl acetophenones open analogues as potent and selective inhibitors of steroid-11β-hydroxylase.
Stefanachi A, Hanke N, Pisani L, Leonetti F, Nicolotti O, Catto M, Cellamare S, Hartmann RW, Carotti A. Stefanachi A, et al. Among authors: nicolotti o. Eur J Med Chem. 2015 Jan 7;89:106-14. doi: 10.1016/j.ejmech.2014.10.021. Epub 2014 Oct 13. Eur J Med Chem. 2015. PMID: 25462231 Free article.
Structure-Based Design and Optimization of Multitarget-Directed 2H-Chromen-2-one Derivatives as Potent Inhibitors of Monoamine Oxidase B and Cholinesterases.
Farina R, Pisani L, Catto M, Nicolotti O, Gadaleta D, Denora N, Soto-Otero R, Mendez-Alvarez E, Passos CS, Muncipinto G, Altomare CD, Nurisso A, Carrupt PA, Carotti A. Farina R, et al. Among authors: nicolotti o. J Med Chem. 2015 Jul 23;58(14):5561-78. doi: 10.1021/acs.jmedchem.5b00599. Epub 2015 Jul 9. J Med Chem. 2015. PMID: 26107513
170 results