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The Jumonji-domain histone demethylase inhibitor JIB-04 deregulates oncogenic programs and increases DNA damage in Ewing Sarcoma, resulting in impaired cell proliferation and survival, and reduced tumor growth.
Parrish JK, McCann TS, Sechler M, Sobral LM, Ren W, Jones KL, Tan AC, Jedlicka P. Parrish JK, et al. Among authors: mccann ts. Oncotarget. 2018 Sep 4;9(69):33110-33123. doi: 10.18632/oncotarget.26011. eCollection 2018 Sep 4. Oncotarget. 2018. PMID: 30237855 Free PMC article.
Functions of the proteasome on chromatin.
McCann TS, Tansey WP. McCann TS, et al. Biomolecules. 2014 Nov 21;4(4):1026-44. doi: 10.3390/biom4041026. Biomolecules. 2014. PMID: 25422899 Free PMC article. Review.