De Santo C - Search Results

1

Metabolic engineering against the arginine microenvironment enhances CAR-T cell proliferation and therapeutic activity.

Fultang L, Booth S, Yogev O, Martins da Costa B, Tubb V, Panetti S, Stavrou V, Scarpa U, Jankevics A, Lloyd G, Southam A, Lee SP, Dunn WB, Chesler L, Mussai F, De Santo C. Fultang L, et al. Among authors: de santo c. Blood. 2020 Sep 3;136(10):1155-1160. doi: 10.1182/blood.2019004500. Blood. 2020. PMID: 32573723 Free PMC article.

2

Invariant NKT cells reduce the immunosuppressive activity of influenza A virus-induced myeloid-derived suppressor cells in mice and humans.

De Santo C, Salio M, Masri SH, Lee LY, Dong T, Speak AO, Porubsky S, Booth S, Veerapen N, Besra GS, Gröne HJ, Platt FM, Zambon M, Cerundolo V. De Santo C, et al. J Clin Invest. 2008 Dec;118(12):4036-48. doi: 10.1172/JCI36264. Epub 2008 Nov 13. J Clin Invest. 2008. PMID: 19033672 Free PMC article.

3

Interaction between invariant NKT cells and myeloid-derived suppressor cells in cancer patients: evidence and therapeutic opportunities.

Mussai F, De Santo C, Cerundolo V. Mussai F, et al. Among authors: de santo c. J Immunother. 2012 Jul;35(6):449-59. doi: 10.1097/CJI.0b013e31825be926. J Immunother. 2012. PMID: 22735803 Review.

4

Acute myeloid leukemia creates an arginase-dependent immunosuppressive microenvironment.

Mussai F, De Santo C, Abu-Dayyeh I, Booth S, Quek L, McEwen-Smith RM, Qureshi A, Dazzi F, Vyas P, Cerundolo V. Mussai F, et al. Among authors: de santo c. Blood. 2013 Aug 1;122(5):749-58. doi: 10.1182/blood-2013-01-480129. Epub 2013 Jun 3. Blood. 2013. PMID: 23733335 Free PMC article.

5

Arginine dependence of acute myeloid leukemia blast proliferation: a novel therapeutic target.

Mussai F, Egan S, Higginbotham-Jones J, Perry T, Beggs A, Odintsova E, Loke J, Pratt G, U KP, Lo A, Ng M, Kearns P, Cheng P, De Santo C. Mussai F, et al. Among authors: de santo c. Blood. 2015 Apr 9;125(15):2386-96. doi: 10.1182/blood-2014-09-600643. Epub 2015 Feb 20. Blood. 2015. PMID: 25710880 Free PMC article.

6

Neuroblastoma Arginase Activity Creates an Immunosuppressive Microenvironment That Impairs Autologous and Engineered Immunity.

Mussai F, Egan S, Hunter S, Webber H, Fisher J, Wheat R, McConville C, Sbirkov Y, Wheeler K, Bendle G, Petrie K, Anderson J, Chesler L, De Santo C. Mussai F, et al. Among authors: de santo c. Cancer Res. 2015 Aug 1;75(15):3043-53. doi: 10.1158/0008-5472.CAN-14-3443. Epub 2015 Jun 8. Cancer Res. 2015. PMID: 26054597 Free PMC article.

7

Molecular basis and current strategies of therapeutic arginine depletion for cancer.

Fultang L, Vardon A, De Santo C, Mussai F. Fultang L, et al. Among authors: de santo c. Int J Cancer. 2016 Aug 1;139(3):501-9. doi: 10.1002/ijc.30051. Epub 2016 Apr 15. Int J Cancer. 2016. PMID: 26913960 Review.

8

Neuroblastoma arginine addiction subverts the anticancer immune response.

De Santo C, Mussai F. De Santo C, et al. Oncoimmunology. 2015 Nov 11;5(2):e1078967. doi: 10.1080/2162402X.2015.1078967. eCollection 2016 Feb. Oncoimmunology. 2015. PMID: 27057459 Free PMC article.

9

Arginine auxotrophic gene signature in paediatric sarcomas and brain tumours provides a viable target for arginine depletion therapies.

Vardon A, Dandapani M, Cheng D, Cheng P, De Santo C, Mussai F. Vardon A, et al. Among authors: de santo c. Oncotarget. 2017 Jun 29;8(38):63506-63517. doi: 10.18632/oncotarget.18843. eCollection 2017 Sep 8. Oncotarget. 2017. PMID: 28969007 Free PMC article.

10

The arginine metabolome in acute lymphoblastic leukemia can be targeted by the pegylated-recombinant arginase I BCT-100.

De Santo C, Booth S, Vardon A, Cousins A, Tubb V, Perry T, Noyvert B, Beggs A, Ng M, Halsey C, Kearns P, Cheng P, Mussai F. De Santo C, et al. Int J Cancer. 2018 Apr 1;142(7):1490-1502. doi: 10.1002/ijc.31170. Epub 2017 Dec 26. Int J Cancer. 2018. PMID: 29168171 Free PMC article.

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