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Distinct pseudokinase domain conformations underlie divergent activation mechanisms among vertebrate MLKL orthologues.
Davies KA, Fitzgibbon C, Young SN, Garnish SE, Yeung W, Coursier D, Birkinshaw RW, Sandow JJ, Lehmann WIL, Liang LY, Lucet IS, Chalmers JD, Patrick WM, Kannan N, Petrie EJ, Czabotar PE, Murphy JM. Davies KA, et al. Among authors: murphy jm. Nat Commun. 2020 Jun 19;11(1):3060. doi: 10.1038/s41467-020-16823-3. Nat Commun. 2020. PMID: 32561735 Free PMC article.
Regulation of Janus kinases by SOCS proteins.
Kershaw NJ, Murphy JM, Lucet IS, Nicola NA, Babon JJ. Kershaw NJ, et al. Among authors: murphy jm. Biochem Soc Trans. 2013 Aug;41(4):1042-7. doi: 10.1042/BST20130077. Biochem Soc Trans. 2013. PMID: 23863176 Free PMC article. Review.
The pseudokinase MLKL mediates necroptosis via a molecular switch mechanism.
Murphy JM, Czabotar PE, Hildebrand JM, Lucet IS, Zhang JG, Alvarez-Diaz S, Lewis R, Lalaoui N, Metcalf D, Webb AI, Young SN, Varghese LN, Tannahill GM, Hatchell EC, Majewski IJ, Okamoto T, Dobson RC, Hilton DJ, Babon JJ, Nicola NA, Strasser A, Silke J, Alexander WS. Murphy JM, et al. Immunity. 2013 Sep 19;39(3):443-53. doi: 10.1016/j.immuni.2013.06.018. Epub 2013 Sep 5. Immunity. 2013. PMID: 24012422 Free article.
A robust methodology to subclassify pseudokinases based on their nucleotide-binding properties.
Murphy JM, Zhang Q, Young SN, Reese ML, Bailey FP, Eyers PA, Ungureanu D, Hammaren H, Silvennoinen O, Varghese LN, Chen K, Tripaydonis A, Jura N, Fukuda K, Qin J, Nimchuk Z, Mudgett MB, Elowe S, Gee CL, Liu L, Daly RJ, Manning G, Babon JJ, Lucet IS. Murphy JM, et al. Biochem J. 2014 Jan 15;457(2):323-34. doi: 10.1042/BJ20131174. Biochem J. 2014. PMID: 24107129 Free PMC article.
794 results