Kannan N - Search Results

1

Distinct pseudokinase domain conformations underlie divergent activation mechanisms among vertebrate MLKL orthologues.

Davies KA, Fitzgibbon C, Young SN, Garnish SE, Yeung W, Coursier D, Birkinshaw RW, Sandow JJ, Lehmann WIL, Liang LY, Lucet IS, Chalmers JD, Patrick WM, Kannan N, Petrie EJ, Czabotar PE, Murphy JM. Davies KA, et al. Among authors: kannan n. Nat Commun. 2020 Jun 19;11(1):3060. doi: 10.1038/s41467-020-16823-3. Nat Commun. 2020. PMID: 32561735 Free PMC article.

2

Covalent inhibitors of EGFR family protein kinases induce degradation of human Tribbles 2 (TRIB2) pseudokinase in cancer cells.

Foulkes DM, Byrne DP, Yeung W, Shrestha S, Bailey FP, Ferries S, Eyers CE, Keeshan K, Wells C, Drewry DH, Zuercher WJ, Kannan N, Eyers PA. Foulkes DM, et al. Among authors: kannan n. Sci Signal. 2018 Sep 25;11(549):eaat7951. doi: 10.1126/scisignal.aat7951. Sci Signal. 2018. PMID: 30254057 Free PMC article.

3

Tracing the origin and evolution of pseudokinases across the tree of life.

Kwon A, Scott S, Taujale R, Yeung W, Kochut KJ, Eyers PA, Kannan N. Kwon A, et al. Among authors: kannan n. Sci Signal. 2019 Apr 23;12(578):eaav3810. doi: 10.1126/scisignal.aav3810. Sci Signal. 2019. PMID: 31015289 Free PMC article.

4

The crystal structure of the protein kinase HIPK2 reveals a unique architecture of its CMGC-insert region.

Agnew C, Liu L, Liu S, Xu W, You L, Yeung W, Kannan N, Jablons D, Jura N. Agnew C, et al. Among authors: kannan n. J Biol Chem. 2019 Sep 13;294(37):13545-13559. doi: 10.1074/jbc.RA119.009725. Epub 2019 Jul 24. J Biol Chem. 2019. PMID: 31341017 Free PMC article.

5

Lipid-targeting pleckstrin homology domain turns its autoinhibitory face toward the TEC kinases.

Amatya N, Wales TE, Kwon A, Yeung W, Joseph RE, Fulton DB, Kannan N, Engen JR, Andreotti AH. Amatya N, et al. Among authors: kannan n. Proc Natl Acad Sci U S A. 2019 Oct 22;116(43):21539-21544. doi: 10.1073/pnas.1907566116. Epub 2019 Oct 7. Proc Natl Acad Sci U S A. 2019. PMID: 31591208 Free PMC article.

6

Cataloguing the dead: breathing new life into pseudokinase research.

Shrestha S, Byrne DP, Harris JA, Kannan N, Eyers PA. Shrestha S, et al. Among authors: kannan n. FEBS J. 2020 Oct;287(19):4150-4169. doi: 10.1111/febs.15246. Epub 2020 Mar 10. FEBS J. 2020. PMID: 32053275 Free PMC article. Review.

7

Emerging roles of the αC-β4 loop in protein kinase structure, function, evolution, and disease.

Yeung W, Ruan Z, Kannan N. Yeung W, et al. Among authors: kannan n. IUBMB Life. 2020 Jun;72(6):1189-1202. doi: 10.1002/iub.2253. Epub 2020 Feb 26. IUBMB Life. 2020. PMID: 32101380 Free PMC article. Review.

8

Deep evolutionary analysis reveals the design principles of fold A glycosyltransferases.

Taujale R, Venkat A, Huang LC, Zhou Z, Yeung W, Rasheed KM, Li S, Edison AS, Moremen KW, Kannan N. Taujale R, et al. Among authors: kannan n. Elife. 2020 Apr 1;9:e54532. doi: 10.7554/eLife.54532. Elife. 2020. PMID: 32234211 Free PMC article.

9

Mutual antagonism between Hippo signaling and cyclin E drives intracellular pattern formation.

Jiang YY, Maier W, Chukka UN, Choromanski M, Lee C, Joachimiak E, Wloga D, Yeung W, Kannan N, Frankel J, Gaertig J. Jiang YY, et al. Among authors: kannan n. J Cell Biol. 2020 Sep 7;219(9):e202002077. doi: 10.1083/jcb.202002077. J Cell Biol. 2020. PMID: 32642758 Free PMC article.

10

Quantitative Structure-Mutation-Activity Relationship Tests (QSMART) model for protein kinase inhibitor response prediction.

Huang LC, Yeung W, Wang Y, Cheng H, Venkat A, Li S, Ma P, Rasheed K, Kannan N. Huang LC, et al. Among authors: kannan n. BMC Bioinformatics. 2020 Nov 12;21(1):520. doi: 10.1186/s12859-020-03842-6. BMC Bioinformatics. 2020. PMID: 33183223 Free PMC article.

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