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Page 1
Distinct pseudokinase domain conformations underlie divergent activation mechanisms among vertebrate MLKL orthologues.
Davies KA, Fitzgibbon C, Young SN, Garnish SE, Yeung W, Coursier D, Birkinshaw RW, Sandow JJ, Lehmann WIL, Liang LY, Lucet IS, Chalmers JD, Patrick WM, Kannan N, Petrie EJ, Czabotar PE, Murphy JM. Davies KA, et al. Among authors: fitzgibbon c. Nat Commun. 2020 Jun 19;11(1):3060. doi: 10.1038/s41467-020-16823-3. Nat Commun. 2020. PMID: 32561735 Free PMC article.
Viral MLKL Homologs Subvert Necroptotic Cell Death by Sequestering Cellular RIPK3.
Petrie EJ, Sandow JJ, Lehmann WIL, Liang LY, Coursier D, Young SN, Kersten WJA, Fitzgibbon C, Samson AL, Jacobsen AV, Lowes KN, Au AE, Jousset Sabroux H, Lalaoui N, Webb AI, Lessene G, Manning G, Lucet IS, Murphy JM. Petrie EJ, et al. Among authors: fitzgibbon c. Cell Rep. 2019 Sep 24;28(13):3309-3319.e5. doi: 10.1016/j.celrep.2019.08.055. Cell Rep. 2019. PMID: 31553902 Free article.
Identification of MLKL membrane translocation as a checkpoint in necroptotic cell death using Monobodies.
Petrie EJ, Birkinshaw RW, Koide A, Denbaum E, Hildebrand JM, Garnish SE, Davies KA, Sandow JJ, Samson AL, Gavin X, Fitzgibbon C, Young SN, Hennessy PJ, Smith PPC, Webb AI, Czabotar PE, Koide S, Murphy JM. Petrie EJ, et al. Among authors: fitzgibbon c. Proc Natl Acad Sci U S A. 2020 Apr 14;117(15):8468-8475. doi: 10.1073/pnas.1919960117. Epub 2020 Mar 31. Proc Natl Acad Sci U S A. 2020. PMID: 32234780 Free PMC article.
MLKL trafficking and accumulation at the plasma membrane control the kinetics and threshold for necroptosis.
Samson AL, Zhang Y, Geoghegan ND, Gavin XJ, Davies KA, Mlodzianoski MJ, Whitehead LW, Frank D, Garnish SE, Fitzgibbon C, Hempel A, Young SN, Jacobsen AV, Cawthorne W, Petrie EJ, Faux MC, Shield-Artin K, Lalaoui N, Hildebrand JM, Silke J, Rogers KL, Lessene G, Hawkins ED, Murphy JM. Samson AL, et al. Among authors: fitzgibbon c. Nat Commun. 2020 Jun 19;11(1):3151. doi: 10.1038/s41467-020-16887-1. Nat Commun. 2020. PMID: 32561730 Free PMC article.
Potent Inhibition of Necroptosis by Simultaneously Targeting Multiple Effectors of the Pathway.
Pierotti CL, Tanzer MC, Jacobsen AV, Hildebrand JM, Garnier JM, Sharma P, Lucet IS, Cowan AD, Kersten WJA, Luo MX, Liang LY, Fitzgibbon C, Garnish SE, Hempel A, Nachbur U, Huang DCS, Czabotar PE, Silke J, van Delft MF, Murphy JM, Lessene G. Pierotti CL, et al. Among authors: fitzgibbon c. ACS Chem Biol. 2020 Oct 16;15(10):2702-2713. doi: 10.1021/acschembio.0c00482. Epub 2020 Sep 22. ACS Chem Biol. 2020. PMID: 32902249
A toolbox for imaging RIPK1, RIPK3, and MLKL in mouse and human cells.
Samson AL, Fitzgibbon C, Patel KM, Hildebrand JM, Whitehead LW, Rimes JS, Jacobsen AV, Horne CR, Gavin XJ, Young SN, Rogers KL, Hawkins ED, Murphy JM. Samson AL, et al. Among authors: fitzgibbon c. Cell Death Differ. 2021 Jul;28(7):2126-2144. doi: 10.1038/s41418-021-00742-x. Epub 2021 Feb 15. Cell Death Differ. 2021. PMID: 33589776 Free PMC article.
Conformational interconversion of MLKL and disengagement from RIPK3 precede cell death by necroptosis.
Garnish SE, Meng Y, Koide A, Sandow JJ, Denbaum E, Jacobsen AV, Yeung W, Samson AL, Horne CR, Fitzgibbon C, Young SN, Smith PPC, Webb AI, Petrie EJ, Hildebrand JM, Kannan N, Czabotar PE, Koide S, Murphy JM. Garnish SE, et al. Among authors: fitzgibbon c. Nat Commun. 2021 Apr 13;12(1):2211. doi: 10.1038/s41467-021-22400-z. Nat Commun. 2021. PMID: 33850121 Free PMC article.
Ubiquitylation of MLKL at lysine 219 positively regulates necroptosis-induced tissue injury and pathogen clearance.
Garcia LR, Tenev T, Newman R, Haich RO, Liccardi G, John SW, Annibaldi A, Yu L, Pardo M, Young SN, Fitzgibbon C, Fernando W, Guppy N, Kim H, Liang LY, Lucet IS, Kueh A, Roxanis I, Gazinska P, Sims M, Smyth T, Ward G, Bertin J, Beal AM, Geddes B, Choudhary JS, Murphy JM, Aurelia Ball K, Upton JW, Meier P. Garcia LR, et al. Among authors: fitzgibbon c. Nat Commun. 2021 Jun 7;12(1):3364. doi: 10.1038/s41467-021-23474-5. Nat Commun. 2021. PMID: 34099649 Free PMC article.
Oligomerization-driven MLKL ubiquitylation antagonizes necroptosis.
Liu Z, Dagley LF, Shield-Artin K, Young SN, Bankovacki A, Wang X, Tang M, Howitt J, Stafford CA, Nachbur U, Fitzgibbon C, Garnish SE, Webb AI, Komander D, Murphy JM, Hildebrand JM, Silke J. Liu Z, et al. Among authors: fitzgibbon c. EMBO J. 2021 Dec 1;40(23):e103718. doi: 10.15252/embj.2019103718. Epub 2021 Oct 26. EMBO J. 2021. PMID: 34698396 Free PMC article.
48 results