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The reaction of hydrogen peroxide with hemoglobin induces extensive alpha-globin crosslinking and impairs the interaction of hemoglobin with endogenous scavenger pathways.
Vallelian F, Pimenova T, Pereira CP, Abraham B, Mikolajczyk MG, Schoedon G, Zenobi R, Alayash AI, Buehler PW, Schaer DJ. Vallelian F, et al. Free Radic Biol Med. 2008 Oct 15;45(8):1150-8. doi: 10.1016/j.freeradbiomed.2008.07.013. Epub 2008 Jul 27. Free Radic Biol Med. 2008. PMID: 18708138
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