Chern TR - Search Results

1

Discovery of Potent Small-Molecule Inhibitors of MLL Methyltransferase.

Chern TR, Liu L, Petrunak E, Stuckey JA, Wang M, Bernard D, Zhou H, Lee S, Dou Y, Wang S. Chern TR, et al. ACS Med Chem Lett. 2020 May 14;11(6):1348-1352. doi: 10.1021/acsmedchemlett.0c00229. eCollection 2020 Jun 11. ACS Med Chem Lett. 2020. PMID: 32551023 Free PMC article.

2

High-Affinity Peptidomimetic Inhibitors of the DCN1-UBC12 Protein-Protein Interaction.

Zhou H, Zhou W, Zhou B, Liu L, Chern TR, Chinnaswamy K, Lu J, Bernard D, Yang CY, Li S, Wang M, Stuckey J, Sun Y, Wang S. Zhou H, et al. Among authors: chern tr. J Med Chem. 2018 Mar 8;61(5):1934-1950. doi: 10.1021/acs.jmedchem.7b01455. Epub 2018 Feb 26. J Med Chem. 2018. PMID: 29438612

3

Design and synthesis of dual-action inhibitors targeting histone deacetylases and 3-hydroxy-3-methylglutaryl coenzyme A reductase for cancer treatment.

Chen JB, Chern TR, Wei TT, Chen CC, Lin JH, Fang JM. Chen JB, et al. Among authors: chern tr. J Med Chem. 2013 May 9;56(9):3645-55. doi: 10.1021/jm400179b. Epub 2013 Apr 22. J Med Chem. 2013. PMID: 23570542

4

Design and synthesis of novel dual-action compounds targeting the adenosine A(2A) receptor and adenosine transporter for neuroprotection.

Chen JB, Liu EM, Chern TR, Yang CW, Lin CI, Huang NK, Lin YL, Chern Y, Lin JH, Fang JM. Chen JB, et al. Among authors: chern y, chern tr. ChemMedChem. 2011 Aug 1;6(8):1390-400. doi: 10.1002/cmdc.201100126. Epub 2011 Jun 20. ChemMedChem. 2011. PMID: 21692183

5

Discovery of N-arylalkyl-3-hydroxy-4-oxo-3,4-dihydroquinazolin-2-carboxamide derivatives as HCV NS5B polymerase inhibitors.

Deore RR, Chen GS, Chang PT, Chern TR, Lai SY, Chuang MH, Lin JH, Kung FL, Chen CS, Chiou CT, Chern JW. Deore RR, et al. Among authors: chern tr. ChemMedChem. 2012 May;7(5):850-60. doi: 10.1002/cmdc.201200058. Epub 2012 Mar 1. ChemMedChem. 2012. PMID: 22383290

6

AID downregulation is a novel function of the DNMT inhibitor 5-aza-deoxycytidine.

Tsai CT, Yang PM, Chern TR, Chuang SH, Lin JH, Klemm L, Müschen M, Chen CC. Tsai CT, et al. Among authors: chern tr. Oncotarget. 2014 Jan 15;5(1):211-23. doi: 10.18632/oncotarget.1319. Oncotarget. 2014. PMID: 24457556 Free PMC article.

7

A newly designed molecule J2326 for Alzheimer's disease disaggregates amyloid fibrils and induces neurite outgrowth.

Chang PT, Talekar RS, Kung FL, Chern TR, Huang CW, Ye QQ, Yang MY, Yu CW, Lai SY, Deore RR, Lin JH, Chen CS, Chen GS, Chern JW. Chang PT, et al. Among authors: chern tr. Neuropharmacology. 2015 May;92:146-57. doi: 10.1016/j.neuropharm.2015.01.004. Epub 2015 Jan 14. Neuropharmacology. 2015. PMID: 25596491

8

Development and use of DJ-1 affinity microcolumns to screen and study small drug candidates for Parkinson's disease.

Jones JC, Lin J, Sharmeen S, Rahman MM, Truong HH, Chern TR, Wilson MA, Hage DS. Jones JC, et al. Among authors: chern tr. Anal Chim Acta. 2025 Jan 22;1336:343520. doi: 10.1016/j.aca.2024.343520. Epub 2024 Dec 2. Anal Chim Acta. 2025. PMID: 39788673

9

Author Correction: AI is a viable alternative to high throughput screening: a 318-target study.

Atomwise AIMS Program. Atomwise AIMS Program. Sci Rep. 2024 Sep 16;14(1):21579. doi: 10.1038/s41598-024-70321-w. Sci Rep. 2024. PMID: 39284864 Free PMC article. No abstract available.

10

AI is a viable alternative to high throughput screening: a 318-target study.

Atomwise AIMS Program. Atomwise AIMS Program. Sci Rep. 2024 Apr 2;14(1):7526. doi: 10.1038/s41598-024-54655-z. Sci Rep. 2024. PMID: 38565852 Free PMC article.

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