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ATI-2173, a Novel Liver-Targeted Non-Chain-Terminating Nucleotide for Hepatitis B Virus Cure Regimens.
Squires KE, Mayers DL, Bluemling GR, Kolykhalov AA, Guthrie DB, Reddy P, Mitchell DG, Saindane MT, Sticher ZM, Edpuganti V, De La Rosa A. Squires KE, et al. Among authors: saindane mt. Antimicrob Agents Chemother. 2020 Aug 20;64(9):e00836-20. doi: 10.1128/AAC.00836-20. Print 2020 Aug 20. Antimicrob Agents Chemother. 2020. PMID: 32540975 Free PMC article.
Small-Molecule Antiviral β-d-N4-Hydroxycytidine Inhibits a Proofreading-Intact Coronavirus with a High Genetic Barrier to Resistance.
Agostini ML, Pruijssers AJ, Chappell JD, Gribble J, Lu X, Andres EL, Bluemling GR, Lockwood MA, Sheahan TP, Sims AC, Natchus MG, Saindane M, Kolykhalov AA, Painter GR, Baric RS, Denison MR. Agostini ML, et al. J Virol. 2019 Nov 26;93(24):e01348-19. doi: 10.1128/JVI.01348-19. Print 2019 Dec 15. J Virol. 2019. PMID: 31578288 Free PMC article.
An orally bioavailable broad-spectrum antiviral inhibits SARS-CoV-2 in human airway epithelial cell cultures and multiple coronaviruses in mice.
Sheahan TP, Sims AC, Zhou S, Graham RL, Pruijssers AJ, Agostini ML, Leist SR, Schäfer A, Dinnon KH 3rd, Stevens LJ, Chappell JD, Lu X, Hughes TM, George AS, Hill CS, Montgomery SA, Brown AJ, Bluemling GR, Natchus MG, Saindane M, Kolykhalov AA, Painter G, Harcourt J, Tamin A, Thornburg NJ, Swanstrom R, Denison MR, Baric RS. Sheahan TP, et al. Sci Transl Med. 2020 Apr 29;12(541):eabb5883. doi: 10.1126/scitranslmed.abb5883. Epub 2020 Apr 6. Sci Transl Med. 2020. PMID: 32253226 Free PMC article.
4'-Fluorouridine mitigates lethal infection with pandemic human and highly pathogenic avian influenza viruses.
Lieber CM, Aggarwal M, Yoon JJ, Cox RM, Kang HJ, Sourimant J, Toots M, Johnson SK, Jones CA, Sticher ZM, Kolykhalov AA, Saindane MT, Tompkins SM, Planz O, Painter GR, Natchus MG, Sakamoto K, Plemper RK. Lieber CM, et al. Among authors: saindane mt. PLoS Pathog. 2023 Apr 17;19(4):e1011342. doi: 10.1371/journal.ppat.1011342. eCollection 2023 Apr. PLoS Pathog. 2023. PMID: 37068076 Free PMC article.
Modeling Heartland virus disease in mice and therapeutic intervention with 4'-fluorouridine.
Westover JB, Jung KH, Alkan C, Boardman KM, Van Wettere AJ, Martens C, Rojas I, Hicks P, Thomas AJ, Saindane MT, Bluemling GR, Mao S, Kolykhalov AA, Natchus MG, Bates P, Painter GR, Ikegami T, Gowen BB. Westover JB, et al. Among authors: saindane mt. J Virol. 2024 Apr 16;98(4):e0013224. doi: 10.1128/jvi.00132-24. Epub 2024 Mar 21. J Virol. 2024. PMID: 38511932 Free PMC article.
Non-nucleoside inhibitors of the measles virus RNA-dependent RNA polymerase: synthesis, structure-activity relationships, and pharmacokinetics.
Ndungu JM, Krumm SA, Yan D, Arrendale RF, Reddy GP, Evers T, Howard R, Natchus MG, Saindane MT, Liotta DC, Plemper RK, Snyder JP, Sun A. Ndungu JM, et al. Among authors: saindane mt. J Med Chem. 2012 May 10;55(9):4220-30. doi: 10.1021/jm201699w. Epub 2012 Apr 20. J Med Chem. 2012. PMID: 22480182 Free PMC article.
An orally available, small-molecule polymerase inhibitor shows efficacy against a lethal morbillivirus infection in a large animal model.
Krumm SA, Yan D, Hovingh ES, Evers TJ, Enkirch T, Reddy GP, Sun A, Saindane MT, Arrendale RF, Painter G, Liotta DC, Natchus MG, von Messling V, Plemper RK. Krumm SA, et al. Among authors: saindane mt. Sci Transl Med. 2014 Apr 16;6(232):232ra52. doi: 10.1126/scitranslmed.3008517. Sci Transl Med. 2014. PMID: 24739760 Free PMC article.
Asymmetric synthesis of host-directed inhibitors of myxoviruses.
Moore TW, Sana K, Yan D, Thepchatri P, Ndungu JM, Saindane MT, Lockwood MA, Natchus MG, Liotta DC, Plemper RK, Snyder JP, Sun A. Moore TW, et al. Among authors: saindane mt. Beilstein J Org Chem. 2013;9:197-203. doi: 10.3762/bjoc.9.23. Epub 2013 Jan 30. Beilstein J Org Chem. 2013. PMID: 23400228 Free PMC article.
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