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Allosteric control of hemoglobin S fiber formation by oxygen and its relation to the pathophysiology of sickle cell disease.
Henry ER, Cellmer T, Dunkelberger EB, Metaferia B, Hofrichter J, Li Q, Ostrowski D, Ghirlando R, Louis JM, Moutereau S, Galactéros F, Thein SL, Bartolucci P, Eaton WA. Henry ER, et al. Among authors: metaferia b. Proc Natl Acad Sci U S A. 2020 Jun 30;117(26):15018-15027. doi: 10.1073/pnas.1922004117. Epub 2020 Jun 11. Proc Natl Acad Sci U S A. 2020. PMID: 32527859 Free PMC article.
Treatment of sickle cell disease by increasing oxygen affinity of hemoglobin.
Henry ER, Metaferia B, Li Q, Harper J, Best RB, Glass KE, Cellmer T, Dunkelberger EB, Conrey A, Thein SL, Bunn HF, Eaton WA. Henry ER, et al. Among authors: metaferia b. Blood. 2021 Sep 30;138(13):1172-1181. doi: 10.1182/blood.2021012070. Blood. 2021. PMID: 34197597 Free PMC article.
Kinetic assay shows that increasing red cell volume could be a treatment for sickle cell disease.
Li Q, Henry ER, Hofrichter J, Smith JF, Cellmer T, Dunkelberger EB, Metaferia BB, Jones-Straehle S, Boutom S, Christoph GW, Wakefield TH, Link ME, Staton D, Vass ER, Miller JL, Hsieh MM, Tisdale JF, Eaton WA. Li Q, et al. Among authors: metaferia bb. Proc Natl Acad Sci U S A. 2017 Jan 31;114(5):E689-E696. doi: 10.1073/pnas.1619054114. Epub 2017 Jan 17. Proc Natl Acad Sci U S A. 2017. PMID: 28096387 Free PMC article.
21 results