Heyes J - Search Results

1

Lipid nanoparticles for nucleic acid delivery: Current perspectives.

Samaridou E, Heyes J, Lutwyche P. Samaridou E, et al. Among authors: heyes j. Adv Drug Deliv Rev. 2020;154-155:37-63. doi: 10.1016/j.addr.2020.06.002. Epub 2020 Jun 8. Adv Drug Deliv Rev. 2020. PMID: 32526452 Review.

2

Lyophilization provides long-term stability for a lipid nanoparticle-formulated, nucleoside-modified mRNA vaccine.

Muramatsu H, Lam K, Bajusz C, Laczkó D, Karikó K, Schreiner P, Martin A, Lutwyche P, Heyes J, Pardi N. Muramatsu H, et al. Among authors: heyes j. Mol Ther. 2022 May 4;30(5):1941-1951. doi: 10.1016/j.ymthe.2022.02.001. Epub 2022 Feb 4. Mol Ther. 2022. PMID: 35131437 Free PMC article.

3

Combination treatment of mannose and GalNAc conjugated small interfering RNA protects against lethal Marburg virus infection.

Ye X, Holland R, Wood M, Pasetka C, Palmer L, Samaridou E, McClintock K, Borisevich V, Geisbert TW, Cross RW, Heyes J. Ye X, et al. Among authors: heyes j. Mol Ther. 2023 Jan 4;31(1):269-281. doi: 10.1016/j.ymthe.2022.09.009. Epub 2022 Sep 15. Mol Ther. 2023. PMID: 36114672 Free PMC article.

4

Combination treatment of mannose and GalNAc conjugated small interfering RNA protects against lethal Marburg virus infection.

Ye X, Holland R, Wood M, Pasetka C, Palmer L, Samaridou E, McClintock K, Borisevich V, Geisbert TW, Cross RW, Heyes J. Ye X, et al. Among authors: heyes j. Mol Ther. 2023 Mar 1;31(3):911-912. doi: 10.1016/j.ymthe.2023.01.015. Epub 2023 Jan 24. Mol Ther. 2023. PMID: 36696896 Free PMC article. No abstract available.

5

Optimizing Lipid Nanoparticles for Delivery in Primates.

Lam K, Schreiner P, Leung A, Stainton P, Reid S, Yaworski E, Lutwyche P, Heyes J. Lam K, et al. Among authors: heyes j. Adv Mater. 2023 Jun;35(26):e2211420. doi: 10.1002/adma.202211420. Epub 2023 May 11. Adv Mater. 2023. PMID: 36972555

6

Ligand conjugate SAR and enhanced delivery in NHP.

Holland RJ, Lam K, Ye X, Martin AD, Wood MC, Palmer L, Fraser D, McClintock K, Majeski S, Jarosz A, Lee ACH, Thi EP, Judge A, Heyes J. Holland RJ, et al. Among authors: heyes j. Mol Ther. 2021 Oct 6;29(10):2910-2919. doi: 10.1016/j.ymthe.2021.06.002. Epub 2021 Jun 4. Mol Ther. 2021. PMID: 34091052 Free PMC article.

7

Added to pre-existing inflammation, mRNA-lipid nanoparticles induce inflammation exacerbation (IE).

Parhiz H, Brenner JS, Patel PN, Papp TE, Shahnawaz H, Li Q, Shi R, Zamora ME, Yadegari A, Marcos-Contreras OA, Natesan A, Pardi N, Shuvaev VV, Kiseleva R, Myerson JW, Uhler T, Riley RS, Han X, Mitchell MJ, Lam K, Heyes J, Weissman D, Muzykantov VR. Parhiz H, et al. Among authors: heyes j. J Control Release. 2022 Apr;344:50-61. doi: 10.1016/j.jconrel.2021.12.027. Epub 2021 Dec 23. J Control Release. 2022. PMID: 34953981 Free PMC article.

8

Unsaturated, Trialkyl Ionizable Lipids are Versatile Lipid-Nanoparticle Components for Therapeutic and Vaccine Applications.

Lam K, Leung A, Martin A, Wood M, Schreiner P, Palmer L, Daly O, Zhao W, McClintock K, Heyes J. Lam K, et al. Among authors: heyes j. Adv Mater. 2023 Apr;35(15):e2209624. doi: 10.1002/adma.202209624. Epub 2023 Mar 5. Adv Mater. 2023. PMID: 36680477

9

Silicon Ether Ionizable Lipids Enable Potent mRNA Lipid Nanoparticles with Rapid Tissue Clearance.

Holland R, Lam K, Jeng S, McClintock K, Palmer L, Schreiner P, Wood M, Zhao W, Heyes J. Holland R, et al. Among authors: heyes j. ACS Nano. 2024 Apr 16;18(15):10374-10387. doi: 10.1021/acsnano.3c09028. Epub 2024 Apr 3. ACS Nano. 2024. PMID: 38567845 Free PMC article.

10

Lipid encapsulation enables the effective systemic delivery of polyplex plasmid DNA.

Heyes J, Palmer L, Chan K, Giesbrecht C, Jeffs L, MacLachlan I. Heyes J, et al. Mol Ther. 2007 Apr;15(4):713-20. doi: 10.1038/sj.mt.6300101. Epub 2007 Feb 13. Mol Ther. 2007. PMID: 17299407 Free article.

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