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Robust ACE2 protein expression localizes to the motile cilia of the respiratory tract epithelia and is not increased by ACE inhibitors or angiotensin receptor blockers.
Lee IT, Nakayama T, Wu CT, Goltsev Y, Jiang S, Gall PA, Liao CK, Shih LC, Schürch CM, McIlwain DR, Chu P, Borchard NA, Zarabanda D, Dholakia SS, Yang A, Kim D, Kanie T, Lin CD, Tsai MH, Phillips KM, Kim R, Overdevest JB, Tyler MA, Yan CH, Lin CF, Lin YT, Bau DT, Tsay GJ, Patel ZM, Tsou YA, Tai CJ, Yeh TH, Hwang PH, Nolan GP, Nayak JV, Jackson PK. Lee IT, et al. Among authors: nakayama t. medRxiv [Preprint]. 2020 May 12:2020.05.08.20092866. doi: 10.1101/2020.05.08.20092866. medRxiv. 2020. Update in: Nat Commun. 2020 Oct 28;11(1):5453. doi: 10.1038/s41467-020-19145-6 PMID: 32511516 Free PMC article. Updated. Preprint.
Mediators of Allergic Asthma and Rhinosinusitis.
Kim YH, Nakayama T, Bau DT. Kim YH, et al. Among authors: nakayama t. Mediators Inflamm. 2017;2017:7405245. doi: 10.1155/2017/7405245. Epub 2017 Oct 4. Mediators Inflamm. 2017. PMID: 29109621 Free PMC article. No abstract available.
ACE2 localizes to the respiratory cilia and is not increased by ACE inhibitors or ARBs.
Lee IT, Nakayama T, Wu CT, Goltsev Y, Jiang S, Gall PA, Liao CK, Shih LC, Schürch CM, McIlwain DR, Chu P, Borchard NA, Zarabanda D, Dholakia SS, Yang A, Kim D, Chen H, Kanie T, Lin CD, Tsai MH, Phillips KM, Kim R, Overdevest JB, Tyler MA, Yan CH, Lin CF, Lin YT, Bau DT, Tsay GJ, Patel ZM, Tsou YA, Tzankov A, Matter MS, Tai CJ, Yeh TH, Hwang PH, Nolan GP, Nayak JV, Jackson PK. Lee IT, et al. Among authors: nakayama t. Nat Commun. 2020 Oct 28;11(1):5453. doi: 10.1038/s41467-020-19145-6. Nat Commun. 2020. PMID: 33116139 Free PMC article.
Ethacridine inhibits SARS-CoV-2 by inactivating viral particles in cellular models.
Li X, Lidsky P, Xiao Y, Wu CT, GarciaKnight M, Yang J, Nakayama T, Nayak JV, Jackson PK, Andino R, Shu X. Li X, et al. Among authors: nakayama t. bioRxiv [Preprint]. 2020 Nov 2:2020.10.28.359042. doi: 10.1101/2020.10.28.359042. bioRxiv. 2020. Update in: PLoS Pathog. 2021 Sep 3;17(9):e1009898. doi: 10.1371/journal.ppat.1009898 PMID: 33140048 Free PMC article. Updated. Preprint.
SARS-CoV-2 infects human pancreatic β cells and elicits β cell impairment.
Wu CT, Lidsky PV, Xiao Y, Lee IT, Cheng R, Nakayama T, Jiang S, Demeter J, Bevacqua RJ, Chang CA, Whitener RL, Stalder AK, Zhu B, Chen H, Goltsev Y, Tzankov A, Nayak JV, Nolan GP, Matter MS, Andino R, Jackson PK. Wu CT, et al. Among authors: nakayama t. Cell Metab. 2021 Aug 3;33(8):1565-1576.e5. doi: 10.1016/j.cmet.2021.05.013. Epub 2021 May 18. Cell Metab. 2021. PMID: 34081912 Free PMC article.
Ethacridine inhibits SARS-CoV-2 by inactivating viral particles.
Li X, Lidsky PV, Xiao Y, Wu CT, Garcia-Knight M, Yang J, Nakayama T, Nayak JV, Jackson PK, Andino R, Shu X. Li X, et al. Among authors: nakayama t. PLoS Pathog. 2021 Sep 3;17(9):e1009898. doi: 10.1371/journal.ppat.1009898. eCollection 2021 Sep. PLoS Pathog. 2021. PMID: 34478458 Free PMC article.
Determinants of SARS-CoV-2 entry and replication in airway mucosal tissue and susceptibility in smokers.
Nakayama T, Lee IT, Jiang S, Matter MS, Yan CH, Overdevest JB, Wu CT, Goltsev Y, Shih LC, Liao CK, Zhu B, Bai Y, Lidsky P, Xiao Y, Zarabanda D, Yang A, Easwaran M, Schürch CM, Chu P, Chen H, Stalder AK, McIlwain DR, Borchard NA, Gall PA, Dholakia SS, Le W, Xu L, Tai CJ, Yeh TH, Erickson-Direnzo E, Duran JM, Mertz KD, Hwang PH, Haslbauer JD, Jackson PK, Menter T, Andino R, Canoll PD, DeConde AS, Patel ZM, Tzankov A, Nolan GP, Nayak JV. Nakayama T, et al. Cell Rep Med. 2021 Oct 19;2(10):100421. doi: 10.1016/j.xcrm.2021.100421. Epub 2021 Sep 28. Cell Rep Med. 2021. PMID: 34604819 Free PMC article.
5,341 results