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Oncometabolites suppress DNA repair by disrupting local chromatin signalling.
Sulkowski PL, Oeck S, Dow J, Economos NG, Mirfakhraie L, Liu Y, Noronha K, Bao X, Li J, Shuch BM, King MC, Bindra RS, Glazer PM. Sulkowski PL, et al. Among authors: liu y. Nature. 2020 Jun;582(7813):586-591. doi: 10.1038/s41586-020-2363-0. Epub 2020 Jun 3. Nature. 2020. PMID: 32494005 Free PMC article.
Targeting cancer with a lupus autoantibody.
Hansen JE, Chan G, Liu Y, Hegan DC, Dalal S, Dray E, Kwon Y, Xu Y, Xu X, Peterson-Roth E, Geiger E, Liu Y, Gera J, Sweasy JB, Sung P, Rockwell S, Nishimura RN, Weisbart RH, Glazer PM. Hansen JE, et al. Among authors: liu y. Sci Transl Med. 2012 Oct 24;4(157):157ra142. doi: 10.1126/scitranslmed.3004385. Sci Transl Med. 2012. PMID: 23100628 Free PMC article.
YU238259 Is a Novel Inhibitor of Homology-Dependent DNA Repair That Exhibits Synthetic Lethality and Radiosensitization in Repair-Deficient Tumors.
Stachelek GC, Peterson-Roth E, Liu Y, Fernandez RJ 3rd, Pike LR, Qian JM, Abriola L, Hoyer D, Hungerford W, Merkel J, Glazer PM. Stachelek GC, et al. Among authors: liu y. Mol Cancer Res. 2015 Oct;13(10):1389-97. doi: 10.1158/1541-7786.MCR-15-0036. Epub 2015 Jun 26. Mol Cancer Res. 2015. PMID: 26116172 Free PMC article.
DNA-dependent targeting of cell nuclei by a lupus autoantibody.
Weisbart RH, Chan G, Jordaan G, Noble PW, Liu Y, Glazer PM, Nishimura RN, Hansen JE. Weisbart RH, et al. Among authors: liu y. Sci Rep. 2015 Jul 9;5:12022. doi: 10.1038/srep12022. Sci Rep. 2015. PMID: 26156563 Free PMC article.
In vivo correction of anaemia in β-thalassemic mice by γPNA-mediated gene editing with nanoparticle delivery.
Bahal R, Ali McNeer N, Quijano E, Liu Y, Sulkowski P, Turchick A, Lu YC, Bhunia DC, Manna A, Greiner DL, Brehm MA, Cheng CJ, López-Giráldez F, Ricciardi A, Beloor J, Krause DS, Kumar P, Gallagher PG, Braddock DT, Mark Saltzman W, Ly DH, Glazer PM. Bahal R, et al. Among authors: liu y. Nat Commun. 2016 Oct 26;7:13304. doi: 10.1038/ncomms13304. Nat Commun. 2016. PMID: 27782131 Free PMC article.
2-Hydroxyglutarate produced by neomorphic IDH mutations suppresses homologous recombination and induces PARP inhibitor sensitivity.
Sulkowski PL, Corso CD, Robinson ND, Scanlon SE, Purshouse KR, Bai H, Liu Y, Sundaram RK, Hegan DC, Fons NR, Breuer GA, Song Y, Mishra-Gorur K, De Feyter HM, de Graaf RA, Surovtseva YV, Kachman M, Halene S, Günel M, Glazer PM, Bindra RS. Sulkowski PL, et al. Among authors: liu y. Sci Transl Med. 2017 Feb 1;9(375):eaal2463. doi: 10.1126/scitranslmed.aal2463. Sci Transl Med. 2017. PMID: 28148839 Free PMC article.
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