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Impact of hypoxia on chemoresistance of mesothelioma mediated by the proton-coupled folate transporter, and preclinical activity of new anti-LDH-A compounds.
Li Petri G, El Hassouni B, Sciarrillo R, Funel N, Mantini G, Zeeuw van der Laan EA, Cascioferro S, Avan A, Zucali PA, Zaffaroni N, Lagerweij T, Parrino B, Smid K, Deraco M, Granchi C, Braczko A, Smolenski RT, Matherly LH, Jansen G, Assaraf YG, Diana P, Cloos J, Peters GJ, Minutolo F, Giovannetti E. Li Petri G, et al. Among authors: granchi c. Br J Cancer. 2020 Aug;123(4):644-656. doi: 10.1038/s41416-020-0912-9. Epub 2020 Jun 4. Br J Cancer. 2020. PMID: 32493992 Free PMC article.
A carrier free delivery system of a MAGL inhibitor is effective on ovarian cancer.
Palazzolo S, Saorin G, Corona G, Granchi C, Tuccinardi T, Kamensek U, Brezar SK, Cemazar M, Canzonieri V, Rizzolio F. Palazzolo S, et al. Among authors: granchi c. Eur J Pharm Biopharm. 2024 Oct;203:114397. doi: 10.1016/j.ejpb.2024.114397. Epub 2024 Jul 6. Eur J Pharm Biopharm. 2024. PMID: 38972466 Free article.
alpha-Naphthylaminopropan-2-ol Derivatives as BACE1 Inhibitors.
Asso V, Ghilardi E, Bertini S, Digiacomo M, Granchi C, Minutolo F, Rapposelli S, Bortolato A, Moro S, Macchia M. Asso V, et al. Among authors: granchi c. ChemMedChem. 2008 Oct;3(10):1530-4. doi: 10.1002/cmdc.200800162. ChemMedChem. 2008. PMID: 18781572 No abstract available.
Discovery of N-hydroxyindole-based inhibitors of human lactate dehydrogenase isoform A (LDH-A) as starvation agents against cancer cells.
Granchi C, Roy S, Giacomelli C, Macchia M, Tuccinardi T, Martinelli A, Lanza M, Betti L, Giannaccini G, Lucacchini A, Funel N, León LG, Giovannetti E, Peters GJ, Palchaudhuri R, Calvaresi EC, Hergenrother PJ, Minutolo F. Granchi C, et al. J Med Chem. 2011 Mar 24;54(6):1599-612. doi: 10.1021/jm101007q. Epub 2011 Feb 18. J Med Chem. 2011. PMID: 21332213
Anticancer agents that counteract tumor glycolysis.
Granchi C, Minutolo F. Granchi C, et al. ChemMedChem. 2012 Aug;7(8):1318-50. doi: 10.1002/cmdc.201200176. Epub 2012 Jun 8. ChemMedChem. 2012. PMID: 22684868 Free PMC article. Review.
116 results