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PGC-1α regulates autophagy to promote fibroblast activation and tissue fibrosis.
Zhang Y, Shen L, Zhu H, Dreissigacker K, Distler D, Zhou X, Györfi AH, Bergmann C, Meng X, Dees C, Trinh-Minh T, Ludolph I, Horch R, Ramming A, Schett G, Distler JHW. Zhang Y, et al. Among authors: shen l. Ann Rheum Dis. 2020 Sep;79(9):1227-1233. doi: 10.1136/annrheumdis-2020-216963. Epub 2020 Jun 1. Ann Rheum Dis. 2020. PMID: 32482644
TGFβ promotes fibrosis by MYST1-dependent epigenetic regulation of autophagy.
Zehender A, Li YN, Lin NY, Stefanica A, Nüchel J, Chen CW, Hsu HH, Zhu H, Ding X, Huang J, Shen L, Györfi AH, Soare A, Rauber S, Bergmann C, Ramming A, Plomann M, Eckes B, Schett G, Distler JHW. Zehender A, et al. Among authors: shen l. Nat Commun. 2021 Jul 20;12(1):4404. doi: 10.1038/s41467-021-24601-y. Nat Commun. 2021. PMID: 34285225 Free PMC article.
Targeting of canonical WNT signaling ameliorates experimental sclerodermatous chronic graft-versus-host disease.
Zhang Y, Shen L, Dreißigacker K, Zhu H, Trinh-Minh T, Meng X, Tran-Manh C, Dees C, Matei AE, Chen CW, Ditschkowski M, Krauss S, Winkler J, Wolff D, Ziemer M, Beilhack A, Karrer S, Herr W, Mackensen A, Schett G, Spriewald BM, Distler JHW. Zhang Y, et al. Among authors: shen l. Blood. 2021 Apr 29;137(17):2403-2416. doi: 10.1182/blood.2020008720. Blood. 2021. PMID: 33529322 Free article.
Altered 3D genome reorganization mediates precocious myeloid differentiation of aged hematopoietic stem cells in inflammation.
Cui X, Dong Y, Zhan Q, Huang Y, Zhu Q, Zhang Z, Yang G, Wang L, Shen S, Zhao J, Lin Z, Sun J, Su Z, Xiao Y, Zhang C, Liang Y, Shen L, Ji L, Zhang X, Yin J, Wang H, Chen Z, Ju Z, Jiang C, Le R, Gao S. Cui X, et al. Among authors: shen l. Sci China Life Sci. 2024 Dec 27. doi: 10.1007/s11427-024-2754-9. Online ahead of print. Sci China Life Sci. 2024. PMID: 39754007
Basic Science and Pathogenesis.
Chongtham A, Farinas M, Broekaart D, Seo JH, Ramakrishnan A, Zhu CW, Sano M, Shen L, Pereira AC. Chongtham A, et al. Among authors: shen l. Alzheimers Dement. 2024 Dec;20 Suppl 1:e084995. doi: 10.1002/alz.084995. Alzheimers Dement. 2024. PMID: 39751798
Basic Science and Pathogenesis.
Nam Y, Woerner J, Jung SH, Suh EH, Shou H, Shen L, Kim D. Nam Y, et al. Among authors: shen l. Alzheimers Dement. 2024 Dec;20 Suppl 1:e084351. doi: 10.1002/alz.084351. Alzheimers Dement. 2024. PMID: 39751773
Basic Science and Pathogenesis.
Xiao X, Jiao B, Yao R, Liao X, Li J, Tang B, Shen L. Xiao X, et al. Among authors: shen l. Alzheimers Dement. 2024 Dec;20 Suppl 1:e087849. doi: 10.1002/alz.087849. Alzheimers Dement. 2024. PMID: 39751497
Basic Science and Pathogenesis.
Shen L, Hao X, Xiao X, Yang Q, Jiao B. Shen L, et al. Alzheimers Dement. 2024 Dec;20 Suppl 1:e087846. doi: 10.1002/alz.087846. Alzheimers Dement. 2024. PMID: 39751455
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