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β-Arrestin-Biased Allosteric Modulator of NTSR1 Selectively Attenuates Addictive Behaviors.
Slosky LM, Bai Y, Toth K, Ray C, Rochelle LK, Badea A, Chandrasekhar R, Pogorelov VM, Abraham DM, Atluri N, Peddibhotla S, Hedrick MP, Hershberger P, Maloney P, Yuan H, Li Z, Wetsel WC, Pinkerton AB, Barak LS, Caron MG. Slosky LM, et al. Among authors: caron mg. Cell. 2020 Jun 11;181(6):1364-1379.e14. doi: 10.1016/j.cell.2020.04.053. Epub 2020 May 28. Cell. 2020. PMID: 32470395 Free PMC article.
ML314: A Biased Neurotensin Receptor Ligand for Methamphetamine Abuse.
Barak LS, Bai Y, Peterson S, Evron T, Urs NM, Peddibhotla S, Hedrick MP, Hershberger P, Maloney PR, Chung TD, Rodriguiz RM, Wetsel WC, Thomas JB, Hanson GR, Pinkerton AB, Caron MG. Barak LS, et al. Among authors: caron mg. ACS Chem Biol. 2016 Jul 15;11(7):1880-90. doi: 10.1021/acschembio.6b00291. Epub 2016 May 5. ACS Chem Biol. 2016. PMID: 27119457 Free PMC article.
A Brief History of the β-Arrestins.
Caron MG, Barak LS. Caron MG, et al. Methods Mol Biol. 2019;1957:3-8. doi: 10.1007/978-1-4939-9158-7_1. Methods Mol Biol. 2019. PMID: 30919344 Free PMC article. Review.
Discovery of β-Arrestin Biased, Orally Bioavailable, and CNS Penetrant Neurotensin Receptor 1 (NTR1) Allosteric Modulators.
Pinkerton AB, Peddibhotla S, Yamamoto F, Slosky LM, Bai Y, Maloney P, Hershberger P, Hedrick MP, Falter B, Ardecky RJ, Smith LH, Chung TDY, Jackson MR, Caron MG, Barak LS. Pinkerton AB, et al. Among authors: caron mg. J Med Chem. 2019 Sep 12;62(17):8357-8363. doi: 10.1021/acs.jmedchem.9b00340. Epub 2019 Aug 20. J Med Chem. 2019. PMID: 31390201 Free PMC article.
Biased Allosteric Modulators: New Frontiers in GPCR Drug Discovery.
Slosky LM, Caron MG, Barak LS. Slosky LM, et al. Among authors: caron mg. Trends Pharmacol Sci. 2021 Apr;42(4):283-299. doi: 10.1016/j.tips.2020.12.005. Epub 2021 Feb 10. Trends Pharmacol Sci. 2021. PMID: 33581873 Free PMC article. Review.
A beta-arrestin 2 signaling complex mediates lithium action on behavior.
Beaulieu JM, Marion S, Rodriguiz RM, Medvedev IO, Sotnikova TD, Ghisi V, Wetsel WC, Lefkowitz RJ, Gainetdinov RR, Caron MG. Beaulieu JM, et al. Among authors: caron mg. Cell. 2008 Jan 11;132(1):125-36. doi: 10.1016/j.cell.2007.11.041. Cell. 2008. PMID: 18191226 Free article.
Triphenylmethane dye activation of beta-arrestin.
Barak LS, Bai Y, Snyder JC, Wang J, Chen W, Caron MG. Barak LS, et al. Among authors: caron mg. Biochemistry. 2013 Aug 13;52(32):5403-14. doi: 10.1021/bi400217r. Epub 2013 Aug 1. Biochemistry. 2013. PMID: 23865508 Free PMC article.
669 results