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N-alkylisatin-based microtubule destabilizers bind to the colchicine site on tubulin and retain efficacy in drug resistant acute lymphoblastic leukemia cell lines with less in vitro neurotoxicity.
Keenan B, Finol-Urdaneta RK, Hope A, Bremner JB, Kavallaris M, Lucena-Agell D, Oliva MÁ, Díaz JF, Vine KL. Keenan B, et al. Cancer Cell Int. 2020 May 15;20:170. doi: 10.1186/s12935-020-01251-6. eCollection 2020. Cancer Cell Int. 2020. PMID: 32467666 Free PMC article.
Modification of C-seco taxoids through ring tethering and substituent replacement leading to effective agents against tumor drug resistance mediated by βIII-Tubulin and P-glycoprotein (P-gp) overexpressions.
Tang Y, Rodríguez-Salarichs J, Zhao Y, Cai P, Estévez-Gallego J, Balaguer-Pérez F, Redondo Horcajo M, Lucena-Agell D, Barasoain I, Díaz JF, Fang WS. Tang Y, et al. Eur J Med Chem. 2017 Sep 8;137:488-503. doi: 10.1016/j.ejmech.2017.06.001. Epub 2017 Jun 3. Eur J Med Chem. 2017. PMID: 28624703
Structural model for differential cap maturation at growing microtubule ends.
Estévez-Gallego J, Josa-Prado F, Ku S, Buey RM, Balaguer FA, Prota AE, Lucena-Agell D, Kamma-Lorger C, Yagi T, Iwamoto H, Duchesne L, Barasoain I, Steinmetz MO, Chrétien D, Kamimura S, Díaz JF, Oliva MA. Estévez-Gallego J, et al. Elife. 2020 Mar 10;9:e50155. doi: 10.7554/eLife.50155. Elife. 2020. PMID: 32151315 Free PMC article.
Two Antagonistic Microtubule Targeting Drugs Act Synergistically to Kill Cancer Cells.
Peronne L, Denarier E, Rai A, Prudent R, Vernet A, Suzanne P, Ramirez-Rios S, Michallet S, Guidetti M, Vollaire J, Lucena-Agell D, Ribba AS, Josserand V, Coll JL, Dallemagne P, Díaz JF, Oliva MÁ, Sadoul K, Akhmanova A, Andrieux A, Lafanechère L. Peronne L, et al. Cancers (Basel). 2020 Aug 6;12(8):2196. doi: 10.3390/cancers12082196. Cancers (Basel). 2020. PMID: 32781579 Free PMC article.
32 results