Wexler RR - Search Results

1

Discovery of a High Affinity, Orally Bioavailable Macrocyclic FXIa Inhibitor with Antithrombotic Activity in Preclinical Species.

Yang W, Wang Y, Lai A, Clark CG, Corte JR, Fang T, Gilligan PJ, Jeon Y, Pabbisetty KB, Rampulla RA, Mathur A, Kaspady M, Neithnadka PR, Arumugam A, Raju S, Rossi KA, Myers JE Jr, Sheriff S, Lou Z, Zheng JJ, Chacko SA, Bozarth JM, Wu Y, Crain EJ, Wong PC, Seiffert DA, Luettgen JM, Lam PYS, Wexler RR, Ewing WR. Yang W, et al. Among authors: wexler rr. J Med Chem. 2020 Jul 9;63(13):7226-7242. doi: 10.1021/acs.jmedchem.0c00464. Epub 2020 Jun 17. J Med Chem. 2020. PMID: 32456431

2

The discovery of DuP 753, a potent, orally active nonpeptide angiotensin II receptor antagonist.

Duncia JV, Carini DJ, Chiu AT, Johnson AL, Price WA, Wong PC, Wexler RR, Timmermans PB. Duncia JV, et al. Among authors: wexler rr. Med Res Rev. 1992 Mar;12(2):149-91. doi: 10.1002/med.2610120203. Med Res Rev. 1992. PMID: 1619965 Review. No abstract available.

3

The discovery of a new class of highly specific nonpeptide angiotensin II receptor antagonists.

Timmermans PB, Carini DJ, Chiu AT, Duncia JV, Price WA Jr, Wells GJ, Wong PC, Johnson AL, Wexler RR. Timmermans PB, et al. Among authors: wexler rr. Am J Hypertens. 1991 Apr;4(4 Pt 2):275S-281S. doi: 10.1093/ajh/4.4.275s. Am J Hypertens. 1991. PMID: 1854452 Review.

4

Balanced AT1/AT2 receptor antagonists. 4. XR510 and related 5-(3-amidopropanoyl)imidazoles possessing equal affinity for the AT1 and AT2 receptors.

Quan ML, Chiu AT, Ellis CD, Wong PC, Wexler RR, Timmermans PB. Quan ML, et al. Among authors: wexler rr. J Med Chem. 1995 Jul 21;38(15):2938-45. doi: 10.1021/jm00015a016. J Med Chem. 1995. PMID: 7636854

5

Discovery of losartan, the first angiotensin II receptor antagonist.

Timmermans PB, Duncia JV, Carini DJ, Chiu AT, Wong PC, Wexler RR, Smith RD. Timmermans PB, et al. Among authors: wexler rr. J Hum Hypertens. 1995 Nov;9 Suppl 5:S3-18. J Hum Hypertens. 1995. PMID: 8583479 Review.

6

Pharmacology of XR510, a potent orally active nonpeptide angiotensin II AT1 receptor antagonist with high affinity for the AT2 receptor subtype.

Wong PC, Quan ML, Saye JM, Bernard R, Crain EJ Jr, McCall DE, Watson CA, Zaspel AM, Smith RD, Wexler RR, et al. Wong PC, et al. Among authors: wexler rr. J Cardiovasc Pharmacol. 1995 Sep;26(3):354-62. doi: 10.1097/00005344-199509000-00003. J Cardiovasc Pharmacol. 1995. PMID: 8583775

7

The de novo design and synthesis of cyclic urea inhibitors of factor Xa: initial SAR studies.

Galemmo RA Jr, Maduskuie TP, Dominguez C, Rossi KA, Knabb RM, Wexler RR, Stouten PF. Galemmo RA Jr, et al. Among authors: wexler rr. Bioorg Med Chem Lett. 1998 Oct 6;8(19):2705-10. doi: 10.1016/s0960-894x(98)00471-5. Bioorg Med Chem Lett. 1998. PMID: 9873607

8

Preparation of meta-amidino-N,N-disubstituted anilines as potent inhibitors of coagulation factor Xa.

Fevig JM, Cacciola J, Alexander RS, Knabb RM, Lam GN, Wong PC, Wexler RR. Fevig JM, et al. Among authors: wexler rr. Bioorg Med Chem Lett. 1998 Nov 17;8(22):3143-8. doi: 10.1016/s0960-894x(98)00574-5. Bioorg Med Chem Lett. 1998. PMID: 9873692

9

Orally active isoxazoline glycoprotein IIb/IIIa antagonists with extended duration of action.

Olson RE, Sielecki TM, Wityak J, Pinto DJ, Batt DG, Frietze WE, Liu J, Tobin AE, Orwat MJ, Di Meo SV, Houghton GC, Lalka GK, Mousa SA, Racanelli AL, Hausner EA, Kapil RP, Rabel SR, Thoolen MJ, Reilly TM, Anderson PS, Wexler RR. Olson RE, et al. Among authors: wexler rr. J Med Chem. 1999 Apr 8;42(7):1178-92. doi: 10.1021/jm980348t. J Med Chem. 1999. PMID: 10197962

10

Design and synthesis of potent and selective 5,6-fused heterocyclic thrombin inhibitors.

Dominguez C, Duffy DE, Han Q, Alexander RS, Galemmo RA Jr, Park JM, Wong PC, Amparo EC, Knabb RM, Luettgen J, Wexler RR. Dominguez C, et al. Among authors: wexler rr. Bioorg Med Chem Lett. 1999 Apr 5;9(7):925-30. doi: 10.1016/s0960-894x(99)00113-4. Bioorg Med Chem Lett. 1999. PMID: 10230612

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