Nicolotti O - Search Results

1

Novel Class of Chalcone Oxime Ethers as Potent Monoamine Oxidase-B and Acetylcholinesterase Inhibitors.

Oh JM, Rangarajan TM, Chaudhary R, Singh RP, Singh M, Singh RP, Tondo AR, Gambacorta N, Nicolotti O, Mathew B, Kim H. Oh JM, et al. Among authors: nicolotti o. Molecules. 2020 May 18;25(10):2356. doi: 10.3390/molecules25102356. Molecules. 2020. PMID: 32443652 Free PMC article.

2

Solid-phase synthesis and insights into structure-activity relationships of safinamide analogues as potent and selective inhibitors of type B monoamine oxidase.

Leonetti F, Capaldi C, Pisani L, Nicolotti O, Muncipinto G, Stefanachi A, Cellamare S, Caccia C, Carotti A. Leonetti F, et al. Among authors: nicolotti o. J Med Chem. 2007 Oct 4;50(20):4909-16. doi: 10.1021/jm070725e. Epub 2007 Sep 7. J Med Chem. 2007. PMID: 17824599

3

Homo- and hetero-bivalent edrophonium-like ammonium salts as highly potent, dual binding site AChE inhibitors.

Leonetti F, Catto M, Nicolotti O, Pisani L, Cappa A, Stefanachi A, Carotti A. Leonetti F, et al. Among authors: nicolotti o. Bioorg Med Chem. 2008 Aug 1;16(15):7450-6. doi: 10.1016/j.bmc.2008.06.022. Epub 2008 Jun 14. Bioorg Med Chem. 2008. PMID: 18585045

4

Discovery of a novel class of potent coumarin monoamine oxidase B inhibitors: development and biopharmacological profiling of 7-[(3-chlorobenzyl)oxy]-4-[(methylamino)methyl]-2H-chromen-2-one methanesulfonate (NW-1772) as a highly potent, selective, reversible, and orally active monoamine oxidase B inhibitor.

Pisani L, Muncipinto G, Miscioscia TF, Nicolotti O, Leonetti F, Catto M, Caccia C, Salvati P, Soto-Otero R, Mendez-Alvarez E, Passeleu C, Carotti A. Pisani L, et al. Among authors: nicolotti o. J Med Chem. 2009 Nov 12;52(21):6685-706. doi: 10.1021/jm9010127. J Med Chem. 2009. PMID: 19810674

5

Design, synthesis, and biological evaluation of coumarin derivatives tethered to an edrophonium-like fragment as highly potent and selective dual binding site acetylcholinesterase inhibitors.

Pisani L, Catto M, Giangreco I, Leonetti F, Nicolotti O, Stefanachi A, Cellamare S, Carotti A. Pisani L, et al. Among authors: nicolotti o. ChemMedChem. 2010 Sep 3;5(9):1616-30. doi: 10.1002/cmdc.201000210. ChemMedChem. 2010. PMID: 20677317

6

Design, synthesis and biological evaluation of coumarin alkylamines as potent and selective dual binding site inhibitors of acetylcholinesterase.

Catto M, Pisani L, Leonetti F, Nicolotti O, Pesce P, Stefanachi A, Cellamare S, Carotti A. Catto M, et al. Among authors: nicolotti o. Bioorg Med Chem. 2013 Jan 1;21(1):146-52. doi: 10.1016/j.bmc.2012.10.045. Epub 2012 Nov 7. Bioorg Med Chem. 2013. PMID: 23199476

7

Discovery, biological evaluation, and structure-activity and -selectivity relationships of 6'-substituted (E)-2-(benzofuran-3(2H)-ylidene)-N-methylacetamides, a novel class of potent and selective monoamine oxidase inhibitors.

Pisani L, Barletta M, Soto-Otero R, Nicolotti O, Mendez-Alvarez E, Catto M, Introcaso A, Stefanachi A, Cellamare S, Altomare C, Carotti A. Pisani L, et al. Among authors: nicolotti o. J Med Chem. 2013 Mar 28;56(6):2651-64. doi: 10.1021/jm4000769. Epub 2013 Mar 13. J Med Chem. 2013. PMID: 23437843

8

Fine molecular tuning at position 4 of 2H-chromen-2-one derivatives in the search of potent and selective monoamine oxidase B inhibitors.

Pisani L, Catto M, Nicolotti O, Grossi G, Di Braccio M, Soto-Otero R, Mendez-Alvarez E, Stefanachi A, Gadaleta D, Carotti A. Pisani L, et al. Among authors: nicolotti o. Eur J Med Chem. 2013;70:723-39. doi: 10.1016/j.ejmech.2013.09.034. Epub 2013 Oct 17. Eur J Med Chem. 2013. PMID: 24231308

9

In silico design of novel 2H-chromen-2-one derivatives as potent and selective MAO-B inhibitors.

Pisani L, Farina R, Nicolotti O, Gadaleta D, Soto-Otero R, Catto M, Di Braccio M, Mendez-Alvarez E, Carotti A. Pisani L, et al. Among authors: nicolotti o. Eur J Med Chem. 2015 Jan 7;89:98-105. doi: 10.1016/j.ejmech.2014.10.029. Epub 2014 Oct 13. Eur J Med Chem. 2015. PMID: 25462230

10

Structure-Based Design and Optimization of Multitarget-Directed 2H-Chromen-2-one Derivatives as Potent Inhibitors of Monoamine Oxidase B and Cholinesterases.

Farina R, Pisani L, Catto M, Nicolotti O, Gadaleta D, Denora N, Soto-Otero R, Mendez-Alvarez E, Passos CS, Muncipinto G, Altomare CD, Nurisso A, Carrupt PA, Carotti A. Farina R, et al. Among authors: nicolotti o. J Med Chem. 2015 Jul 23;58(14):5561-78. doi: 10.1021/acs.jmedchem.5b00599. Epub 2015 Jul 9. J Med Chem. 2015. PMID: 26107513

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