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A systematic molecular and pharmacologic evaluation of AKT inhibitors reveals new insight into their biological activity.
Kostaras E, Kaserer T, Lazaro G, Heuss SF, Hussain A, Casado P, Hayes A, Yandim C, Palaskas N, Yu Y, Schwartz B, Raynaud F, Chung YL, Cutillas PR, Vivanco I. Kostaras E, et al. Among authors: vivanco i. Br J Cancer. 2020 Aug;123(4):542-555. doi: 10.1038/s41416-020-0889-4. Epub 2020 May 22. Br J Cancer. 2020. PMID: 32439931 Free PMC article.
Inhibitors in AKTion: ATP-competitive vs allosteric.
Lazaro G, Kostaras E, Vivanco I. Lazaro G, et al. Among authors: vivanco i. Biochem Soc Trans. 2020 Jun 30;48(3):933-943. doi: 10.1042/BST20190777. Biochem Soc Trans. 2020. PMID: 32453400 Free PMC article. Review.
Targeting un-MET needs in advanced non-small cell lung cancer.
Coleman N, Harbery A, Heuss S, Vivanco I, Popat S. Coleman N, et al. Among authors: vivanco i. Lung Cancer. 2022 Feb;164:56-68. doi: 10.1016/j.lungcan.2021.12.016. Epub 2021 Dec 29. Lung Cancer. 2022. PMID: 35033939 Review.
Targeting molecular addictions in cancer.
Vivanco I. Vivanco I. Br J Cancer. 2014 Nov 25;111(11):2033-8. doi: 10.1038/bjc.2014.461. Epub 2014 Sep 30. Br J Cancer. 2014. PMID: 25268375 Free PMC article. Review.
The phosphatase and tensin homolog regulates epidermal growth factor receptor (EGFR) inhibitor response by targeting EGFR for degradation.
Vivanco I, Rohle D, Versele M, Iwanami A, Kuga D, Oldrini B, Tanaka K, Dang J, Kubek S, Palaskas N, Hsueh T, Evans M, Mulholland D, Wolle D, Rajasekaran S, Rajasekaran A, Liau LM, Cloughesy TF, Dikic I, Brennan C, Wu H, Mischel PS, Perera T, Mellinghoff IK. Vivanco I, et al. Proc Natl Acad Sci U S A. 2010 Apr 6;107(14):6459-64. doi: 10.1073/pnas.0911188107. Epub 2010 Mar 22. Proc Natl Acad Sci U S A. 2010. PMID: 20308550 Free PMC article.
Differential sensitivity of glioma- versus lung cancer-specific EGFR mutations to EGFR kinase inhibitors.
Vivanco I, Robins HI, Rohle D, Campos C, Grommes C, Nghiemphu PL, Kubek S, Oldrini B, Chheda MG, Yannuzzi N, Tao H, Zhu S, Iwanami A, Kuga D, Dang J, Pedraza A, Brennan CW, Heguy A, Liau LM, Lieberman F, Yung WK, Gilbert MR, Reardon DA, Drappatz J, Wen PY, Lamborn KR, Chang SM, Prados MD, Fine HA, Horvath S, Wu N, Lassman AB, DeAngelis LM, Yong WH, Kuhn JG, Mischel PS, Mehta MP, Cloughesy TF, Mellinghoff IK. Vivanco I, et al. Cancer Discov. 2012 May;2(5):458-71. doi: 10.1158/2159-8290.CD-11-0284. Epub 2012 Mar 31. Cancer Discov. 2012. PMID: 22588883 Free PMC article.
33 results