Pearson PG - Search Results

1

Applications of tandem mass spectrometry to the characterization of derivatized glutathione conjugates. Studies with S-(N-methylcarbamoyl)glutathione, a metabolite of the antineoplastic agent N-methylformamide.

Pearson PG, Threadgill MD, Howald WN, Baillie TA. Pearson PG, et al. Biomed Environ Mass Spectrom. 1988 Oct;16(1-12):51-6. doi: 10.1002/bms.1200160110. Biomed Environ Mass Spectrom. 1988. PMID: 3242707

2

The use of mass spectrometry in the study of chemically-reactive drug metabolites. Application of MS/MS and LC/MS to the analysis of glutathione- and related S-linked conjugates of N-methylformamide.

Baillie TA, Pearson PG, Rashed MS, Howald WN. Baillie TA, et al. Among authors: pearson pg. J Pharm Biomed Anal. 1989;7(12):1351-60. doi: 10.1016/0731-7085(89)80140-2. J Pharm Biomed Anal. 1989. PMID: 2490521

3

Application of liquid chromatography/thermospray mass spectrometry to studies on the formation of glutathione and cysteine conjugates from monomethylcarbamate metabolites of bambuterol.

Rashed MS, Pearson PG, Han DH, Baillie TA. Rashed MS, et al. Among authors: pearson pg. Rapid Commun Mass Spectrom. 1989 Oct;3(10):360-3. doi: 10.1002/rcm.1290031012. Rapid Commun Mass Spectrom. 1989. PMID: 2520219

4

Biotransformation of methyl isocyanate in the rat. Evidence for glutathione conjugation as a major pathway of metabolism and implications for isocyanate-mediated toxicities.

Slatter JG, Rashed MS, Pearson PG, Han DH, Baillie TA. Slatter JG, et al. Among authors: pearson pg. Chem Res Toxicol. 1991 Mar-Apr;4(2):157-61. doi: 10.1021/tx00020a006. Chem Res Toxicol. 1991. PMID: 1782345

5

Carbamoylation of peptides and proteins in vitro by S-(N-methylcarbamoyl)glutathione and S-(N-methylcarbamoyl)cysteine, two electrophilic S-linked conjugates of methyl isocyanate.

Pearson PG, Slatter JG, Rashed MS, Han DH, Baillie TA. Pearson PG, et al. Chem Res Toxicol. 1991 Jul-Aug;4(4):436-44. doi: 10.1021/tx00022a007. Chem Res Toxicol. 1991. PMID: 1912331

6

S-(N-methylcarbamoyl)glutathione: a reactive S-linked metabolite of methyl isocyanate.

Pearson PG, Slatter JG, Rashed MS, Han DH, Grillo MP, Baillie TA. Pearson PG, et al. Biochem Biophys Res Commun. 1990 Jan 15;166(1):245-50. doi: 10.1016/0006-291x(90)91937-n. Biochem Biophys Res Commun. 1990. PMID: 2302207

7

Metabolism of N-methylformamide in mice: primary kinetic deuterium isotope effect and identification of S-(N-methylcarbamoyl)glutathione as a metabolite.

Threadgill MD, Axworthy DB, Baillie TA, Farmer PB, Farrow KC, Gescher A, Kestell P, Pearson PG, Shaw AJ. Threadgill MD, et al. Among authors: pearson pg. J Pharmacol Exp Ther. 1987 Jul;242(1):312-9. J Pharmacol Exp Ther. 1987. PMID: 3612534

8

Studies on the metabolic fate of caracemide, an experimental antitumor agent, in the rat. Evidence for the release of methyl isocyanate in vivo.

Slatter JG, Davis MR, Han DH, Pearson PG, Baillie TA. Slatter JG, et al. Among authors: pearson pg. Chem Res Toxicol. 1993 May-Jun;6(3):335-40. doi: 10.1021/tx00033a013. Chem Res Toxicol. 1993. PMID: 8318655

9

Chemical synthesis and cytotoxic properties of N-alkylcarbamic acid thioesters, metabolites of hepatotoxic formamides.

Han DH, Pearson PG, Baillie TA, Dayal R, Tsang LH, Gescher A. Han DH, et al. Among authors: pearson pg. Chem Res Toxicol. 1990 Mar-Apr;3(2):118-24. doi: 10.1021/tx00014a006. Chem Res Toxicol. 1990. PMID: 2130938

10

Hepatotoxicity of N-methylformamide in mice--II. Covalent binding of metabolites of [14C]-labelled N-methylformamide to hepatic proteins.

Pearson PG, Gescher A, Harpur ES, Threadgill MD. Pearson PG, et al. Biochem Pharmacol. 1987 Feb 1;36(3):385-90. doi: 10.1016/0006-2952(87)90299-1. Biochem Pharmacol. 1987. PMID: 3814178

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