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Page 1
A helminth-derived suppressor of ST2 blocks allergic responses.
Vacca F, Chauché C, Jamwal A, Hinchy EC, Heieis G, Webster H, Ogunkanbi A, Sekne Z, Gregory WF, Wear M, Perona-Wright G, Higgins MK, Nys JA, Cohen ES, McSorley HJ. Vacca F, et al. Among authors: hinchy ec. Elife. 2020 May 18;9:e54017. doi: 10.7554/eLife.54017. Elife. 2020. PMID: 32420871 Free PMC article.
Selective Disruption of Mitochondrial Thiol Redox State in Cells and In Vivo.
Booty LM, Gawel JM, Cvetko F, Caldwell ST, Hall AR, Mulvey JF, James AM, Hinchy EC, Prime TA, Arndt S, Beninca C, Bright TP, Clatworthy MR, Ferdinand JR, Prag HA, Logan A, Prudent J, Krieg T, Hartley RC, Murphy MP. Booty LM, et al. Among authors: hinchy ec. Cell Chem Biol. 2019 Mar 21;26(3):449-461.e8. doi: 10.1016/j.chembiol.2018.12.002. Epub 2019 Jan 31. Cell Chem Biol. 2019. PMID: 30713096 Free PMC article.
Selective mitochondrial superoxide generation in vivo is cardioprotective through hormesis.
Antonucci S, Mulvey JF, Burger N, Di Sante M, Hall AR, Hinchy EC, Caldwell ST, Gruszczyk AV, Deshwal S, Hartley RC, Kaludercic N, Murphy MP, Di Lisa F, Krieg T. Antonucci S, et al. Among authors: hinchy ec. Free Radic Biol Med. 2019 Apr;134:678-687. doi: 10.1016/j.freeradbiomed.2019.01.034. Epub 2019 Feb 4. Free Radic Biol Med. 2019. PMID: 30731114 Free PMC article.
Succinate accumulation drives ischaemia-reperfusion injury during organ transplantation.
Martin JL, Costa ASH, Gruszczyk AV, Beach TE, Allen FM, Prag HA, Hinchy EC, Mahbubani K, Hamed M, Tronci L, Nikitopoulou E, James AM, Krieg T, Robinson AJ, Huang MM, Caldwell ST, Logan A, Pala L, Hartley RC, Frezza C, Saeb-Parsy K, Murphy MP. Martin JL, et al. Among authors: hinchy ec. Nat Metab. 2019 Sep 30;1:966-974. doi: 10.1038/s42255-019-0115-y. Nat Metab. 2019. PMID: 32395697 Free PMC article.
APOPT1/COA8 assists COX assembly and is oppositely regulated by UPS and ROS.
Signes A, Cerutti R, Dickson AS, Benincá C, Hinchy EC, Ghezzi D, Carrozzo R, Bertini E, Murphy MP, Nathan JA, Viscomi C, Fernandez-Vizarra E, Zeviani M. Signes A, et al. Among authors: hinchy ec. EMBO Mol Med. 2019 Jan;11(1):e9582. doi: 10.15252/emmm.201809582. EMBO Mol Med. 2019. PMID: 30552096 Free PMC article.
Malonylation of GAPDH is an inflammatory signal in macrophages.
Galván-Peña S, Carroll RG, Newman C, Hinchy EC, Palsson-McDermott E, Robinson EK, Covarrubias S, Nadin A, James AM, Haneklaus M, Carpenter S, Kelly VP, Murphy MP, Modis LK, O'Neill LA. Galván-Peña S, et al. Among authors: hinchy ec. Nat Commun. 2019 Jan 18;10(1):338. doi: 10.1038/s41467-018-08187-6. Nat Commun. 2019. PMID: 30659183 Free PMC article.
Tozorakimab (MEDI3506): an anti-IL-33 antibody that inhibits IL-33 signalling via ST2 and RAGE/EGFR to reduce inflammation and epithelial dysfunction.
England E, Rees DG, Scott IC, Carmen S, Chan DTY, Chaillan Huntington CE, Houslay KF, Erngren T, Penney M, Majithiya JB, Rapley L, Sims DA, Hollins C, Hinchy EC, Strain MD, Kemp BP, Corkill DJ, May RD, Vousden KA, Butler RJ, Mustelin T, Vaughan TJ, Lowe DC, Colley C, Cohen ES. England E, et al. Among authors: hinchy ec. Sci Rep. 2023 Jun 17;13(1):9825. doi: 10.1038/s41598-023-36642-y. Sci Rep. 2023. PMID: 37330528 Free PMC article.