Hruby VJ - Search Results

1

Melanocortin 3 receptor activation with [D-Trp8]-γ-MSH suppresses inflammation in apolipoprotein E deficient mice.

Kadiri JJ, Thapa K, Kaipio K, Cai M, Hruby VJ, Rinne P. Kadiri JJ, et al. Among authors: hruby vj. Eur J Pharmacol. 2020 Aug 5;880:173186. doi: 10.1016/j.ejphar.2020.173186. Epub 2020 May 13. Eur J Pharmacol. 2020. PMID: 32416182 Free article.

2

Design of novel melanocortin receptor ligands: multiple receptors, complex pharmacology, the challenge.

Hruby VJ, Cai M, Cain J, Nyberg J, Trivedi D. Hruby VJ, et al. Eur J Pharmacol. 2011 Jun 11;660(1):88-93. doi: 10.1016/j.ejphar.2010.10.109. Epub 2011 Jan 3. Eur J Pharmacol. 2011. PMID: 21208601 Free PMC article. Review.

3

The Melanocortin Receptor System: A Target for Multiple Degenerative Diseases.

Cai M, Hruby VJ. Cai M, et al. Among authors: hruby vj. Curr Protein Pept Sci. 2016;17(5):488-96. doi: 10.2174/1389203717666160226145330. Curr Protein Pept Sci. 2016. PMID: 26916163 Free PMC article. Review.

4

Design of novel melanotropin agonists and antagonists with high potency and selectivity for human melanocortin receptors.

Cai M, Mayorov AV, Ying J, Stankova M, Trivedi D, Cabello C, Hruby VJ. Cai M, et al. Among authors: hruby vj. Peptides. 2005 Aug;26(8):1481-5. doi: 10.1016/j.peptides.2005.03.020. Peptides. 2005. PMID: 15876475 Review.

5

Design, synthesis and biological evaluation of ligands selective for the melanocortin-3 receptor.

Hruby VJ, Cai M, Cain JP, Mayorov AV, Dedek MM, Trivedi D. Hruby VJ, et al. Curr Top Med Chem. 2007;7(11):1107-19. doi: 10.2174/156802607780906645. Curr Top Med Chem. 2007. PMID: 17584128 Free PMC article. Review.

6

Substitution of arginine with proline and proline derivatives in melanocyte-stimulating hormones leads to selectivity for human melanocortin 4 receptor.

Qu H, Cai M, Mayorov AV, Grieco P, Zingsheim M, Trivedi D, Hruby VJ. Qu H, et al. Among authors: hruby vj. J Med Chem. 2009 Jun 25;52(12):3627-35. doi: 10.1021/jm801300c. J Med Chem. 2009. PMID: 19473029 Free PMC article.

7

Melanotropins as drugs for the treatment of obesity and other feeding disorders: potential and problems.

Cai M, Nyberg J, Hruby VJ. Cai M, et al. Among authors: hruby vj. Curr Top Med Chem. 2009;9(6):554-63. doi: 10.2174/156802609788897817. Curr Top Med Chem. 2009. PMID: 19689365 Free PMC article. Review.

8

Utilize conjugated melanotropins for the earlier diagnosis and treatment of melanoma.

Cai M, Liu Z, Qu H, Fan H, Zheng Z, Hruby VJ. Cai M, et al. Among authors: hruby vj. Eur J Pharmacol. 2011 Jun 11;660(1):188-93. doi: 10.1016/j.ejphar.2011.01.032. Epub 2011 Feb 16. Eur J Pharmacol. 2011. PMID: 21315067 Free PMC article.

9

α-Melanocyte-stimulating hormone regulates vascular NO availability and protects against endothelial dysfunction.

Rinne P, Nordlund W, Heinonen I, Penttinen AM, Saraste A, Ruohonen ST, Mäkelä S, Vähätalo L, Kaipio K, Cai M, Hruby VJ, Ruohonen S, Savontaus E. Rinne P, et al. Among authors: hruby vj. Cardiovasc Res. 2013 Feb 1;97(2):360-8. doi: 10.1093/cvr/cvs335. Epub 2012 Nov 5. Cardiovasc Res. 2013. PMID: 23131503 Free PMC article.

10

An unusual conformation of γ-melanocyte-stimulating hormone analogues leads to a selective human melanocortin 1 receptor antagonist for targeting melanoma cells.

Cai M, Stankova M, Muthu D, Mayorov A, Yang Z, Trivedi D, Cabello C, Hruby VJ. Cai M, et al. Among authors: hruby vj. Biochemistry. 2013 Jan 29;52(4):752-64. doi: 10.1021/bi300723f. Epub 2013 Jan 15. Biochemistry. 2013. PMID: 23276279 Free PMC article.

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