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TET1 promotes growth of T-cell acute lymphoblastic leukemia and can be antagonized via PARP inhibition.
Bamezai S, Demir D, Pulikkottil AJ, Ciccarone F, Fischbein E, Sinha A, Borga C, Te Kronnie G, Meyer LH, Mohr F, Götze M, Caiafa P, Debatin KM, Döhner K, Döhner H, González-Menéndez I, Quintanilla-Fend L, Herold T, Jeremias I, Feuring-Buske M, Buske C, Rawat VPS. Bamezai S, et al. Among authors: sinha a. Leukemia. 2021 Feb;35(2):389-403. doi: 10.1038/s41375-020-0864-3. Epub 2020 May 15. Leukemia. 2021. PMID: 32409690
Npm1 haploinsufficiency in collaboration with MEIS1 is sufficient to induce AML in mice.
Muranyi A, Ammer T, Kechter A, Rawat VPS, Sinha A, Gonzalez-Menendez I, Quintanilla-Martinez L, Azoitei A, Günes C, Mupo A, Vassiliou G, Bamezai S, Buske C. Muranyi A, et al. Among authors: sinha a. Blood Adv. 2023 Feb 14;7(3):351-364. doi: 10.1182/bloodadvances.2022007015. Blood Adv. 2023. PMID: 35468619 Free PMC article.
Cell of origin determines clinically relevant subtypes of MLL-rearranged AML.
Krivtsov AV, Figueroa ME, Sinha AU, Stubbs MC, Feng Z, Valk PJ, Delwel R, Döhner K, Bullinger L, Kung AL, Melnick AM, Armstrong SA. Krivtsov AV, et al. Among authors: sinha au. Leukemia. 2013 Apr;27(4):852-60. doi: 10.1038/leu.2012.363. Epub 2012 Dec 13. Leukemia. 2013. PMID: 23235717 Free PMC article.
KRas(G12D)-evoked leukemogenesis does not require β-catenin.
Ng CE, Sinha A, Krivtsov A, Dias S, Chang J, Armstrong SA, Kalaitzidis D. Ng CE, et al. Among authors: sinha a. Leukemia. 2014 Mar;28(3):698-702. doi: 10.1038/leu.2013.328. Epub 2013 Nov 5. Leukemia. 2014. PMID: 24189294 Free PMC article. No abstract available.
MLL-rearranged B lymphoblastic leukemias selectively express the immunoregulatory carbohydrate-binding protein galectin-1.
Juszczynski P, Rodig SJ, Ouyang J, O'Donnell E, Takeyama K, Mlynarski W, Mycko K, Szczepanski T, Gaworczyk A, Krivtsov A, Faber J, Sinha AU, Rabinovich GA, Armstrong SA, Kutok JL, Shipp MA. Juszczynski P, et al. Among authors: sinha au. Clin Cancer Res. 2010 Apr 1;16(7):2122-30. doi: 10.1158/1078-0432.CCR-09-2765. Epub 2010 Mar 23. Clin Cancer Res. 2010. PMID: 20332322 Free PMC article.
4,393 results