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254 results

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Pharmacophore Identification and Scaffold Exploration to Discover Novel, Potent, and Chemically Stable Inhibitors of Acid Ceramidase in Melanoma Cells.
Ortega JA, Arencibia JM, La Sala G, Borgogno M, Bauer I, Bono L, Braccia C, Armirotti A, Girotto S, Ganesan A, De Vivo M. Ortega JA, et al. Among authors: la sala g. J Med Chem. 2017 Jul 13;60(13):5800-5815. doi: 10.1021/acs.jmedchem.7b00472. Epub 2017 Jun 27. J Med Chem. 2017. PMID: 28603987 Free article.
Structure-based design of CDC42 effector interaction inhibitors for the treatment of cancer.
Jahid S, Ortega JA, Vuong LM, Acquistapace IM, Hachey SJ, Flesher JL, La Serra MA, Brindani N, La Sala G, Manigrasso J, Arencibia JM, Bertozzi SM, Summa M, Bertorelli R, Armirotti A, Jin R, Liu Z, Chen CF, Edwards R, Hughes CCW, De Vivo M, Ganesan AK. Jahid S, et al. Among authors: la serra ma, la sala g. Cell Rep. 2022 Apr 5;39(1):110641. doi: 10.1016/j.celrep.2022.110641. Cell Rep. 2022. PMID: 35385746 Free PMC article.
Innovative Non-PrP-Targeted Drug Strategy Designed to Enhance Prion Clearance.
Colini Baldeschi A, Zattoni M, Vanni S, Nikolic L, Ferracin C, La Sala G, Summa M, Bertorelli R, Bertozzi SM, Giachin G, Carloni P, Bolognesi ML, De Vivo M, Legname G. Colini Baldeschi A, et al. Among authors: la sala g. J Med Chem. 2022 Jul 14;65(13):8998-9010. doi: 10.1021/acs.jmedchem.2c00205. Epub 2022 Jun 30. J Med Chem. 2022. PMID: 35771181 Free PMC article.
Combining structural and coevolution information to unveil allosteric sites.
La Sala G, Pfleger C, Käck H, Wissler L, Nevin P, Böhm K, Janet JP, Schimpl M, Stubbs CJ, De Vivo M, Tyrchan C, Hogner A, Gohlke H, Frolov AI. La Sala G, et al. Chem Sci. 2023 Jun 8;14(25):7057-7067. doi: 10.1039/d2sc06272k. eCollection 2023 Jun 28. Chem Sci. 2023. PMID: 37389247 Free PMC article.
Studies on the ATP Binding Site of Fyn Kinase for the Identification of New Inhibitors and Their Evaluation as Potential Agents against Tauopathies and Tumors.
Tintori C, La Sala G, Vignaroli G, Botta L, Fallacara AL, Falchi F, Radi M, Zamperini C, Dreassi E, Dello Iacono L, Orioli D, Biamonti G, Garbelli M, Lossani A, Gasparrini F, Tuccinardi T, Laurenzana I, Angelucci A, Maga G, Schenone S, Brullo C, Musumeci F, Desogus A, Crespan E, Botta M. Tintori C, et al. Among authors: la sala g. J Med Chem. 2015 Jun 11;58(11):4590-609. doi: 10.1021/acs.jmedchem.5b00140. Epub 2015 May 20. J Med Chem. 2015. PMID: 25923950
254 results