Georgeon S - Search Results

1

Btk SH2-kinase interface is critical for allosteric kinase activation and its targeting inhibits B-cell neoplasms.

Duarte DP, Lamontanara AJ, La Sala G, Jeong S, Sohn YK, Panjkovich A, Georgeon S, Kükenshöner T, Marcaida MJ, Pojer F, De Vivo M, Svergun D, Kim HS, Dal Peraro M, Hantschel O. Duarte DP, et al. Among authors: georgeon s. Nat Commun. 2020 May 8;11(1):2319. doi: 10.1038/s41467-020-16128-5. Nat Commun. 2020. PMID: 32385234 Free PMC article.

2

Specificity and mechanism-of-action of the JAK2 tyrosine kinase inhibitors ruxolitinib and SAR302503 (TG101348).

Zhou T, Georgeon S, Moser R, Moore DJ, Caflisch A, Hantschel O. Zhou T, et al. Among authors: georgeon s. Leukemia. 2014 Feb;28(2):404-7. doi: 10.1038/leu.2013.205. Epub 2013 Jul 4. Leukemia. 2014. PMID: 23823659 No abstract available.

3

Dissection of the BCR-ABL signaling network using highly specific monobody inhibitors to the SHP2 SH2 domains.

Sha F, Gencer EB, Georgeon S, Koide A, Yasui N, Koide S, Hantschel O. Sha F, et al. Among authors: georgeon s. Proc Natl Acad Sci U S A. 2013 Sep 10;110(37):14924-9. doi: 10.1073/pnas.1303640110. Epub 2013 Aug 26. Proc Natl Acad Sci U S A. 2013. PMID: 23980151 Free PMC article.

4

c-Abl phosphorylates α-synuclein and regulates its degradation: implication for α-synuclein clearance and contribution to the pathogenesis of Parkinson's disease.

Mahul-Mellier AL, Fauvet B, Gysbers A, Dikiy I, Oueslati A, Georgeon S, Lamontanara AJ, Bisquertt A, Eliezer D, Masliah E, Halliday G, Hantschel O, Lashuel HA. Mahul-Mellier AL, et al. Among authors: georgeon s. Hum Mol Genet. 2014 Jun 1;23(11):2858-79. doi: 10.1093/hmg/ddt674. Epub 2014 Jan 9. Hum Mol Genet. 2014. PMID: 24412932 Free PMC article.

5

The SH2 domain of Abl kinases regulates kinase autophosphorylation by controlling activation loop accessibility.

Lamontanara AJ, Georgeon S, Tria G, Svergun DI, Hantschel O. Lamontanara AJ, et al. Among authors: georgeon s. Nat Commun. 2014 Nov 17;5:5470. doi: 10.1038/ncomms6470. Nat Commun. 2014. PMID: 25399951 Free article.

6

Differential signaling networks of Bcr-Abl p210 and p190 kinases in leukemia cells defined by functional proteomics.

Reckel S, Hamelin R, Georgeon S, Armand F, Jolliet Q, Chiappe D, Moniatte M, Hantschel O. Reckel S, et al. Among authors: georgeon s. Leukemia. 2017 Jul;31(7):1502-1512. doi: 10.1038/leu.2017.36. Epub 2017 Jan 23. Leukemia. 2017. PMID: 28111465 Free PMC article.

7

Kinase-templated abiotic reaction.

Saarbach J, Lindberg E, Folliet S, Georgeon S, Hantschel O, Winssinger N. Saarbach J, et al. Among authors: georgeon s. Chem Sci. 2017 Jul 1;8(7):5119-5125. doi: 10.1039/c7sc01416c. Epub 2017 May 24. Chem Sci. 2017. PMID: 28970898 Free PMC article.

8

Single-molecule kinetic analysis of HP1-chromatin binding reveals a dynamic network of histone modification and DNA interactions.

Bryan LC, Weilandt DR, Bachmann AL, Kilic S, Lechner CC, Odermatt PD, Fantner GE, Georgeon S, Hantschel O, Hatzimanikatis V, Fierz B. Bryan LC, et al. Among authors: georgeon s. Nucleic Acids Res. 2017 Oct 13;45(18):10504-10517. doi: 10.1093/nar/gkx697. Nucleic Acids Res. 2017. PMID: 28985346 Free PMC article.

9

Structural and functional dissection of the DH and PH domains of oncogenic Bcr-Abl tyrosine kinase.

Reckel S, Gehin C, Tardivon D, Georgeon S, Kükenshöner T, Löhr F, Koide A, Buchner L, Panjkovich A, Reynaud A, Pinho S, Gerig B, Svergun D, Pojer F, Güntert P, Dötsch V, Koide S, Gavin AC, Hantschel O. Reckel S, et al. Among authors: georgeon s. Nat Commun. 2017 Dec 13;8(1):2101. doi: 10.1038/s41467-017-02313-6. Nat Commun. 2017. PMID: 29235475 Free PMC article.

10

Rapid Screen for Tyrosine Kinase Inhibitor Resistance Mutations and Substrate Specificity.

Taft JM, Georgeon S, Allen C, Reckel S, DeSautelle J, Hantschel O, Georgiou G, Iverson BL. Taft JM, et al. Among authors: georgeon s. ACS Chem Biol. 2019 Sep 20;14(9):1888-1895. doi: 10.1021/acschembio.9b00283. Epub 2019 Aug 8. ACS Chem Biol. 2019. PMID: 31339688

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