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FTY720/fingolimod increases NPC1 and NPC2 expression and reduces cholesterol and sphingolipid accumulation in Niemann-Pick type C mutant fibroblasts.
Newton J, Hait NC, Maceyka M, Colaco A, Maczis M, Wassif CA, Cougnoux A, Porter FD, Milstien S, Platt N, Platt FM, Spiegel S. Newton J, et al. FASEB J. 2017 Apr;31(4):1719-1730. doi: 10.1096/fj.201601041R. Epub 2017 Jan 12. FASEB J. 2017. PMID: 28082351 Free PMC article.
Because neurodegeneration is the main clinical feature of NPC disease, and FTY720 accumulates in the CNS and has several advantages over available histone deacetylase inhibitors now in clinical trials, our work provides a potential opportunity for treatment of this incurable dise …
Because neurodegeneration is the main clinical feature of NPC disease, and FTY720 accumulates in the CNS and has several advantages over ava …
[No title available]
[No authors listed] [No authors listed] PMID: 33516506
CRISPR/Cas9 deletion of ORMDLs reveals complexity in sphingolipid metabolism.
Green CD, Weigel C, Oyeniran C, James BN, Davis D, Mahawar U, Newton J, Wattenberg BW, Maceyka M, Spiegel S. Green CD, et al. Among authors: newton j. J Lipid Res. 2021;62:100082. doi: 10.1016/j.jlr.2021.100082. Epub 2021 Apr 30. J Lipid Res. 2021. PMID: 33939982 Free PMC article.
Ceramide in apoptosis and oxidative stress in allergic inflammation and asthma.
James BN, Oyeniran C, Sturgill JL, Newton J, Martin RK, Bieberich E, Weigel C, Maczis MA, Palladino END, Lownik JC, Trudeau JB, Cook-Mills JM, Wenzel S, Milstien S, Spiegel S. James BN, et al. Among authors: newton j. J Allergy Clin Immunol. 2021 May;147(5):1936-1948.e9. doi: 10.1016/j.jaci.2020.10.024. Epub 2020 Oct 29. J Allergy Clin Immunol. 2021. PMID: 33130063 Free PMC article.
2,378 results